國立虎尾科技大學 |

Admixture dynamics, natural selection and diseases in admixed populations

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Admixture dynamics, natural selection and diseases in admixed populations/ by Wenfei Jin.
作者:	Jin, Wenfei.
出版者:	Dordrecht :Imprint: Springer, : 2015.,
面頁冊數:	xix, 114 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Genetics and Population Dynamics. -
電子資源:	http://dx.doi.org/10.1007/978-94-017-7408-6
ISBN:	9789401774086

Admixture dynamics, natural selection and diseases in admixed populations
Jin, Wenfei.

Admixture dynamics, natural selection and diseases in admixed populations[electronic resource] /by Wenfei Jin. - Dordrecht :Imprint: Springer,2015. - xix, 114 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Distribution of length of ancestral chromosomal segments in admixed genomes -- Exploring population admixture dynamics via distribution of LACS -- Genome-wide search for signatures of natural selection in African Americans -- Complex selective forces shaping the genes underlying human diseases -- Materials and Methods.

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

ISBN: 9789401774086

Standard No.: 10.1007/978-94-017-7408-6doiSubjects--Topical Terms:

670124
Genetics and Population Dynamics.

LC Class. No.: QH546 / .J56 2015

Dewey Class. No.: 578.4

Admixture dynamics, natural selection and diseases in admixed populations
LDR:02435nam a2200325 a 4500 001 838092
003 DE-He213
005 20160418091955.0
006 m d
007 cr nn 008maaau
008 160616s2015 ne s 0 eng d
020 $a 9789401774086 $q (electronic bk.)
020 $a 9789401774062 $q (paper)
024 7 $a 10.1007/978-94-017-7408-6 $2 doi
035 $a 978-94-017-7408-6
040 $a GP $c GP
041 0 $a eng
050 4 $a QH546 $b .J56 2015
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
082 0 4 $a 578.4 $2 23
090 $a QH546 $b .J61 2015
100 1 $a Jin, Wenfei. $3 1069026
245 1 0 $a Admixture dynamics, natural selection and diseases in admixed populations $h [electronic resource] / $c by Wenfei Jin.
260 $a Dordrecht : $c 2015. $b Imprint: Springer, $b Springer Netherlands :
300 $a xix, 114 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Distribution of length of ancestral chromosomal segments in admixed genomes -- Exploring population admixture dynamics via distribution of LACS -- Genome-wide search for signatures of natural selection in African Americans -- Complex selective forces shaping the genes underlying human diseases -- Materials and Methods.
520 $a In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
650 2 4 $a Genetics and Population Dynamics. $3 670124
650 2 4 $a Bioinformatics. $3 583857
650 2 4 $a Human Genetics. $3 593893
650 1 4 $a Biomedicine. $3 593880
650 0 $a Disease susceptibility. $3 685492
650 0 $a Human gene mapping. $3 863066
650 0 $a Genomes. $3 600075
650 0 $a Human evolution. $3 564173
650 0 $a Adaptation (Biology) $3 581700
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 831604
856 4 0 $u http://dx.doi.org/10.1007/978-94-017-7408-6
950 $a Biomedical and Life Sciences (Springer-11642)