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Molecular mechanisms in the pathogenesis of idiopathic nephrotic syndrome

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Molecular mechanisms in the pathogenesis of idiopathic nephrotic syndrome/ edited by Kazunari Kaneko.
其他作者:	Kaneko, Kazunari.
出版者:	Tokyo :Springer Japan : : 2016.,
面頁冊數:	viii, 240 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Nephrotic syndrome - Pathogenesis. -
電子資源:	http://dx.doi.org/10.1007/978-4-431-55270-3
ISBN:	9784431552703

Molecular mechanisms in the pathogenesis of idiopathic nephrotic syndrome
Molecular mechanisms in the pathogenesis of idiopathic nephrotic syndrome[electronic resource] /edited by Kazunari Kaneko. - Tokyo :Springer Japan :2016. - viii, 240 p. :ill., digital ;24 cm.

This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN) As the word "idiopathic" indicates, the pathogenesis of INS remains unclear. Historically, T-cell dysfunction has been thought to play an important part in the pathogenesis of MCNS, while circulating vascular permeabilities have been believed to induce proteinuria in FSGS. The book further describes recent advances in molecular biology, which have allowed us to speculate on the interactions between visceral glomerular epithelial cells (podocytes) and the relative significance of several molecules in the pathogenesis of INS, such as reactive oxygen species, nuclear factor-kappa B, CD80, angiopoietin-like 4, cardiotrophin-like cytokine-1, and M-type phospholipase A2 receptor. The normally rapid pace of scientific progress occasionally devolves into a state of chaos, and the pathogenetic research on INS is one such case. This volume will help researchers and scientists to collaborate, share resources, and expedite the design of protocols to evaluate the putative factors.

ISBN: 9784431552703

Standard No.: 10.1007/978-4-431-55270-3doiSubjects--Topical Terms:

1103252
Nephrotic syndrome
--Pathogenesis.

LC Class. No.: RC918.N43

Dewey Class. No.: 616.61

Molecular mechanisms in the pathogenesis of idiopathic nephrotic syndrome
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