國立虎尾科技大學 |

Novel (trans)dermal drug delivery strategies = micro- and nano-scale assessments /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Novel (trans)dermal drug delivery strategies/ by Hazel Garvie-Cook.
其他題名:	micro- and nano-scale assessments /
作者:	Garvie-Cook, Hazel.
出版者:	Cham :Springer International Publishing : : 2016.,
面頁冊數:	xviii, 114 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Drug delivery systems. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-28901-4
ISBN:	9783319289014

Novel (trans)dermal drug delivery strategies = micro- and nano-scale assessments /
Garvie-Cook, Hazel.

Novel (trans)dermal drug delivery strategiesmicro- and nano-scale assessments /[electronic resource] :by Hazel Garvie-Cook. - Cham :Springer International Publishing :2016. - xviii, 114 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Background -- Methodology -- TEC Plasticization of Topical Polymeric Films -- Lipid Incorporation into Topical Polymeric Films -- Laser Microporation of Skin -- Conclusion.

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

ISBN: 9783319289014

Standard No.: 10.1007/978-3-319-28901-4doiSubjects--Topical Terms:

581921
Drug delivery systems.

LC Class. No.: RS199.5

Dewey Class. No.: 615.6

Novel (trans)dermal drug delivery strategies = micro- and nano-scale assessments /
LDR:02423nam a2200337 a 4500 001 862298
003 DE-He213
005 20160818151905.0
006 m d
007 cr nn 008maaau
008 170720s2016 gw s 0 eng d
020 $a 9783319289014 $q (electronic bk.)
020 $a 9783319289007 $q (paper)
024 7 $a 10.1007/978-3-319-28901-4 $2 doi
035 $a 978-3-319-28901-4
040 $a GP $c GP
041 0 $a eng
050 4 $a RS199.5
072 7 $a MMPH $2 bicssc
072 7 $a PNRL $2 bicssc
072 7 $a SCI058000 $2 bisacsh
082 0 4 $a 615.6 $2 23
090 $a RS199.5 $b .G244 2016
100 1 $a Garvie-Cook, Hazel. $3 1105561
245 1 0 $a Novel (trans)dermal drug delivery strategies $h [electronic resource] : $b micro- and nano-scale assessments / $c by Hazel Garvie-Cook.
260 $a Cham : $c 2016. $b Springer International Publishing : $b Imprint: Springer,
300 $a xviii, 114 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Background -- Methodology -- TEC Plasticization of Topical Polymeric Films -- Lipid Incorporation into Topical Polymeric Films -- Laser Microporation of Skin -- Conclusion.
520 $a This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
650 0 $a Drug delivery systems. $3 581921
650 0 $a Drug delivery systems $x Technological innovations. $3 1105562
650 0 $a Transdermal medication. $3 582003
650 0 $a Bioelectronics. $3 775161
650 1 4 $a Physics. $3 564049
650 2 4 $a Medical and Radiation Physics. $3 784894
650 2 4 $a Biomedical Engineering/Biotechnology. $3 1068811
650 2 4 $a Polymer Sciences. $3 671409
650 2 4 $a Biomedical Engineering. $3 588771
650 2 4 $a Nanotechnology. $3 557660
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 831604
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-28901-4
950 $a Physics and Astronomy (Springer-11651)