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Protein tyrosine phosphatases in cancer

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Protein tyrosine phosphatases in cancer/ edited by Benjamin G. Neel, Nicholas K. Tonks.
other author:	Neel, Benjamin G.
Published:	New York, NY :Springer New York : : 2016.,
Description:	viii, 360 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Cancer - Molecular aspects. -
Online resource:	http://dx.doi.org/10.1007/978-1-4939-3649-6
ISBN:	9781493936496

Protein tyrosine phosphatases in cancer
Protein tyrosine phosphatases in cancer[electronic resource] /edited by Benjamin G. Neel, Nicholas K. Tonks. - New York, NY :Springer New York :2016. - viii, 360 p. :ill. (some col.), digital ;24 cm.

1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective.

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.

ISBN: 9781493936496

Standard No.: 10.1007/978-1-4939-3649-6doiSubjects--Topical Terms:

668357
Cancer
--Molecular aspects.

LC Class. No.: RC262

Dewey Class. No.: 616.994

Protein tyrosine phosphatases in cancer
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245 0 0 $a Protein tyrosine phosphatases in cancer $h [electronic resource] / $c edited by Benjamin G. Neel, Nicholas K. Tonks.
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300 $a viii, 360 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a 1 Introduction to the PTP Superfamily -- 2 Receptor PTPs in Cancer -- 3 Non-Receptor PTPs in Cancer -- 4 HP2 -- 5 C-PTP -- 6 PTP1B -- 7 PTP-PEST -- 8 Dual Specificity Phosphatases in Cancer -- 9 Phosphatase-dependent roles for PTEN in Cancer -- 10 Phosphatase-independent roles for PTEN in Cancer -- 11 PRL family members in Cancer -- 12 Cdc25 family -- 13 PTPs, metabolism and cancer -- 14 PTPs, metabolism and cancer -- 15 Current status of PTP-based therapeutics -- 16 Summary and Perspective.
520 $a This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer, from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry.
650 0 $a Cancer $x Molecular aspects. $3 668357
650 0 $a Protein-tyrosine phosphatase. $3 1112137
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Cancer Research. $3 668358
650 2 4 $a Cell Biology. $3 593889
650 2 4 $a Posttranslational Modification. $3 786934
700 1 $a Neel, Benjamin G. $3 1112135
700 1 $a Tonks, Nicholas K. $3 1112136
710 2 $a SpringerLink (Online service) $3 593884
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856 4 0 $u http://dx.doi.org/10.1007/978-1-4939-3649-6
950 $a Biomedical and Life Sciences (Springer-11642)