國立虎尾科技大學 |

Translating molecular biomarkers into clinical assays = techniques and applications /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Translating molecular biomarkers into clinical assays/ edited by Russell Weiner, Marian Kelley.
Reminder of title:	techniques and applications /
other author:	Weiner, Russell.
Published:	Cham :Springer International Publishing : : 2016.,
Description:	xi, 212 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Biochemical markers. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-40793-7
ISBN:	9783319407937

Translating molecular biomarkers into clinical assays = techniques and applications /
Translating molecular biomarkers into clinical assaystechniques and applications /[electronic resource] :edited by Russell Weiner, Marian Kelley. - Cham :Springer International Publishing :2016. - xi, 212 p. :ill., digital ;24 cm. - AAPS advances in the pharmaceutical sciences series,2210-7371. - AAPS advances in the pharmaceutical sciences series..

Foreword -- Fit-For-Purpose Validation -- Biomarkers in Drug Discovery and Development: Pre-Analytical and Analytical Considerations -- Biomarker Discovery -- Application of Quantitative Biomeasures in Early Drug Discovery -- Biomarkers in discovery and preclinical phase during drug development -- Incorporating clinical biomarkers into clinical trials -- Perspectives on Tissue Biobanking for Personalized Medicine -- The role of commercial biomarker assay kits in preclinical and clinical trials kits -- Quantification of protein biomarkers using liquid chromatography tandem mass spectrometry -- LC/MS methods for small Molecule biomarkers -- Cell-based Assays -- New Technologies for Cellular Analysis -- Flow cytometry methods for the Clinical Development of Immunomodulatory Biologics -- Key mass spectrometry techniques used in clinical biomarker research -- Clinical Genomic Biomarker Assay Development: Technologies and Issues -- Implementation of Immunohistochemistry assays for clinical trial sample analyses -- Strategic Approach to Outsourcing Clinical Biomarker Assays through CRO Relationships -- In situ hybridization (ISH) in Clinical Biomarker Development.

This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are selected for novel and sound research; information is chosen based on its relevance to lab applications and clinical trials, such as the topic of selecting animal models for their relevancy to humans. The book is multifaceted, discussing the ethics and issues with biospecimens and providing an in-depth analysis to the differences between pre-clinical and clinical assay development. The book is an essential read for general readers who need an introduction to the history and background of biomarkers, and it also provides critical analyses of various new validation methods for practitioners and researchers.

ISBN: 9783319407937

Standard No.: 10.1007/978-3-319-40793-7doiSubjects--Topical Terms:

582469
Biochemical markers.

LC Class. No.: R853.B54

Dewey Class. No.: 610.72

Translating molecular biomarkers into clinical assays = techniques and applications /
LDR:03254nam a2200325 a 4500 001 866161
003 DE-He213
005 20160822160441.0
006 m d
007 cr nn 008maaau
008 170720s2016 gw s 0 eng d
020 $a 9783319407937 $q (electronic bk.)
020 $a 9783319407920 $q (paper)
024 7 $a 10.1007/978-3-319-40793-7 $2 doi
035 $a 978-3-319-40793-7
040 $a GP $c GP
041 0 $a eng
050 4 $a R853.B54
072 7 $a TDCW $2 bicssc
072 7 $a MED072000 $2 bisacsh
082 0 4 $a 610.72 $2 23
090 $a R853.B54 $b T772 2016
245 0 0 $a Translating molecular biomarkers into clinical assays $h [electronic resource] : $b techniques and applications / $c edited by Russell Weiner, Marian Kelley.
260 $a Cham : $c 2016. $b Springer International Publishing : $b Imprint: Springer,
300 $a xi, 212 p. : $b ill., digital ; $c 24 cm.
490 1 $a AAPS advances in the pharmaceutical sciences series, $x 2210-7371
505 0 $a Foreword -- Fit-For-Purpose Validation -- Biomarkers in Drug Discovery and Development: Pre-Analytical and Analytical Considerations -- Biomarker Discovery -- Application of Quantitative Biomeasures in Early Drug Discovery -- Biomarkers in discovery and preclinical phase during drug development -- Incorporating clinical biomarkers into clinical trials -- Perspectives on Tissue Biobanking for Personalized Medicine -- The role of commercial biomarker assay kits in preclinical and clinical trials kits -- Quantification of protein biomarkers using liquid chromatography tandem mass spectrometry -- LC/MS methods for small Molecule biomarkers -- Cell-based Assays -- New Technologies for Cellular Analysis -- Flow cytometry methods for the Clinical Development of Immunomodulatory Biologics -- Key mass spectrometry techniques used in clinical biomarker research -- Clinical Genomic Biomarker Assay Development: Technologies and Issues -- Implementation of Immunohistochemistry assays for clinical trial sample analyses -- Strategic Approach to Outsourcing Clinical Biomarker Assays through CRO Relationships -- In situ hybridization (ISH) in Clinical Biomarker Development.
520 $a This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are selected for novel and sound research; information is chosen based on its relevance to lab applications and clinical trials, such as the topic of selecting animal models for their relevancy to humans. The book is multifaceted, discussing the ethics and issues with biospecimens and providing an in-depth analysis to the differences between pre-clinical and clinical assay development. The book is an essential read for general readers who need an introduction to the history and background of biomarkers, and it also provides critical analyses of various new validation methods for practitioners and researchers.
650 0 $a Biochemical markers. $3 582469
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Pharmaceutical Sciences/Technology. $3 768561
650 2 4 $a Pharmacy. $3 582411
700 1 $a Weiner, Russell. $3 1112182
700 1 $a Kelley, Marian. $3 1112183
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a AAPS advances in the pharmaceutical sciences series. $3 1023465
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-40793-7
950 $a Biomedical and Life Sciences (Springer-11642)