國立虎尾科技大學 |

Cancer biomarkers in body fluids = principles /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Cancer biomarkers in body fluids/ by Gabriel D. Dakubo.
其他題名:	principles /
作者:	Dakubo, Gabriel D.
出版者:	Cham :Springer International Publishing : : 2016.,
面頁冊數:	xvi, 299 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Cancer - Molecular diagnosis. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-01580-4
ISBN:	9783319015804

Cancer biomarkers in body fluids = principles /
Dakubo, Gabriel D.

Cancer biomarkers in body fluidsprinciples /[electronic resource] :by Gabriel D. Dakubo. - Cham :Springer International Publishing :2016. - xvi, 299 p. :ill., digital ;24 cm.

The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the "liquid biopsy" concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well. This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.

ISBN: 9783319015804

Standard No.: 10.1007/978-3-319-01580-4doiSubjects--Topical Terms:

867879
Cancer
--Molecular diagnosis.

LC Class. No.: RC270

Dewey Class. No.: 616.9940756

Cancer biomarkers in body fluids = principles /
LDR:02545nam a2200301 a 4500 001 866808
003 DE-He213
005 20160901122758.0
006 m d
007 cr nn 008maaau
008 170720s2016 gw s 0 eng d
020 $a 9783319015804 $q (electronic bk.)
020 $a 9783319015798 $q (paper)
024 7 $a 10.1007/978-3-319-01580-4 $2 doi
035 $a 978-3-319-01580-4
040 $a GP $c GP
041 0 $a eng
050 4 $a RC270
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
082 0 4 $a 616.9940756 $2 23
090 $a RC270 $b .D135 2016
100 1 $a Dakubo, Gabriel D. $3 1113276
245 1 0 $a Cancer biomarkers in body fluids $h [electronic resource] : $b principles / $c by Gabriel D. Dakubo.
260 $a Cham : $c 2016. $b Springer International Publishing : $b Imprint: Springer,
300 $a xvi, 299 p. : $b ill., digital ; $c 24 cm.
520 $a The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the "liquid biopsy" concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well. This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.
650 0 $a Cancer $x Molecular diagnosis. $3 867879
650 0 $a Cancer $x Genetic aspects. $3 782504
650 0 $a Biochemical markers. $3 582469
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Human Genetics. $3 593893
650 2 4 $a Oncology. $3 593951
650 2 4 $a Cancer Research. $3 668358
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-01580-4
950 $a Biomedical and Life Sciences (Springer-11642)