國立虎尾科技大學 |

Thyroid hormone disruption and neurodevelopment

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Thyroid hormone disruption and neurodevelopment/ edited by Noriyuki Koibuchi, Paul M. Yen.
other author:	Koibuchi, Noriyuki.
Published:	New York, NY :Springer New York : : 2016.,
Description:	viii, 209 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Thyroid hormones. -
Online resource:	http://dx.doi.org/10.1007/978-1-4939-3737-0
ISBN:	9781493937370

Thyroid hormone disruption and neurodevelopment
Thyroid hormone disruption and neurodevelopment[electronic resource] /edited by Noriyuki Koibuchi, Paul M. Yen. - New York, NY :Springer New York :2016. - viii, 209 p. :ill., digital ;24 cm. - Contemporary clinical neuroscience. - Contemporary clinical neuroscience..

Section 1: Disruption of thyroid hormone action at molecular level -- 1 Molecular mechanisms of thyroid hormone action in brain: a general overview -- 2 Deoidinases and brain development -- 3 Disruption of thyroid hormone receptor-mediated action in brain by endocrine disrupting chemicals -- 4 Chemical disruption of deiodinase activities during pregnancy and fetal neurotoxicity -- 5 Effect of maternal/neonatal infection on thyroid hormone-mediated neurodevelopment -- 6 Disruption of feedback regulation of thyroid hormone synthesis/secretion and brain development -- Section 2: Animal models to study thyroid hormone disruption on neurodevelopment -- 7 Animal models to study thyroid hormone action in neurodevelopment -- 8 Thyroid hormone receptor mutation and neurodevelopment -- 9 Pax6 knockout and cerebellar development -- 10 Disruption of auditory function by thyroid hormone receptor mutation -- Section 3 Thyroid hormone disruption and neurodevelopment: human studies -- 11 Maternal hypothyroidism and brain development of newborns -- 12 Congenital hypothyroidism and neurodevelopment -- 13 Iodine deficiency and brain development -- 14 Deficit in thyroid hormone transporters and brain development -- 15 Syndrome of resistance to thyroid hormone and brain development.

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a "repressor" of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.

ISBN: 9781493937370

Standard No.: 10.1007/978-1-4939-3737-0doiSubjects--Topical Terms:

793690
Thyroid hormones.

LC Class. No.: QP572.T5 / T49 2016

Dewey Class. No.: 612.44

Thyroid hormone disruption and neurodevelopment
LDR:04126nam a2200325 a 4500 001 867956
003 DE-He213
005 20161112121411.0
006 m d
007 cr nn 008maaau
008 170720s2016 nyu s 0 eng d
020 $a 9781493937370 $q (electronic bk.)
020 $a 9781493937356 $q (paper)
024 7 $a 10.1007/978-1-4939-3737-0 $2 doi
035 $a 978-1-4939-3737-0
040 $a GP $c GP
041 0 $a eng
050 4 $a QP572.T5 $b T49 2016
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
082 0 4 $a 612.44 $2 23
090 $a QP572.T5 $b 549 2016
245 0 0 $a Thyroid hormone disruption and neurodevelopment $h [electronic resource] / $c edited by Noriyuki Koibuchi, Paul M. Yen.
260 $a New York, NY : $b Springer New York : $b Imprint: Springer, $c 2016.
300 $a viii, 209 p. : $b ill., digital ; $c 24 cm.
490 1 $a Contemporary clinical neuroscience
505 0 $a Section 1: Disruption of thyroid hormone action at molecular level -- 1 Molecular mechanisms of thyroid hormone action in brain: a general overview -- 2 Deoidinases and brain development -- 3 Disruption of thyroid hormone receptor-mediated action in brain by endocrine disrupting chemicals -- 4 Chemical disruption of deiodinase activities during pregnancy and fetal neurotoxicity -- 5 Effect of maternal/neonatal infection on thyroid hormone-mediated neurodevelopment -- 6 Disruption of feedback regulation of thyroid hormone synthesis/secretion and brain development -- Section 2: Animal models to study thyroid hormone disruption on neurodevelopment -- 7 Animal models to study thyroid hormone action in neurodevelopment -- 8 Thyroid hormone receptor mutation and neurodevelopment -- 9 Pax6 knockout and cerebellar development -- 10 Disruption of auditory function by thyroid hormone receptor mutation -- Section 3 Thyroid hormone disruption and neurodevelopment: human studies -- 11 Maternal hypothyroidism and brain development of newborns -- 12 Congenital hypothyroidism and neurodevelopment -- 13 Iodine deficiency and brain development -- 14 Deficit in thyroid hormone transporters and brain development -- 15 Syndrome of resistance to thyroid hormone and brain development.
520 $a Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a "repressor" of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.
650 0 $a Thyroid hormones. $3 793690
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Neurosciences. $3 593561
650 2 4 $a Endocrinology. $3 645497
650 2 4 $a Neurology. $3 593894
700 1 $a Koibuchi, Noriyuki. $3 1071681
700 1 $a Yen, Paul M. $3 1115214
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Contemporary clinical neuroscience. $3 1064885
856 4 0 $u http://dx.doi.org/10.1007/978-1-4939-3737-0
950 $a Biomedical and Life Sciences (Springer-11642)