國立虎尾科技大學 |

Efflux-mediated antimicrobial resistance in bacteria = mechanisms, regulation and clinical implications /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Efflux-mediated antimicrobial resistance in bacteria/ edited by Xian-Zhi Li, Christopher A. Elkins, Helen I. Zgurskaya.
其他題名:	mechanisms, regulation and clinical implications /
其他作者:	Li, Xian-Zhi.
出版者:	Cham :Springer International Publishing : : 2016.,
面頁冊數:	xxi, 848 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Drug resistance in microorganisms. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-39658-3
ISBN:	9783319396583

Efflux-mediated antimicrobial resistance in bacteria = mechanisms, regulation and clinical implications /
Efflux-mediated antimicrobial resistance in bacteriamechanisms, regulation and clinical implications /[electronic resource] :edited by Xian-Zhi Li, Christopher A. Elkins, Helen I. Zgurskaya. - Cham :Springer International Publishing :2016. - xxi, 848 p. :ill., digital ;24 cm.

I-Bacterial drug efflux pumps: structures and transport mechanisms -- 1.Structures and transport mechanisms of RND efflux pumps -- 2.Structural and molecular landscape of MFS and MATE efflux pumps -- 3.Small multidrug resistance efflux pumps -- 4.Structures and transport mechanisms of the ABC efflux pumps -- 5.Multidrug efflux in the context of two-membrane cell envelopes -- II-Bacterial drug efflux pumps in antimicrobial resistance: substrates, regulation and clinical significance -- 6.Antimicrobial resistance in bacteria: an overview of mechanisms and role of drug efflux pumps -- 7.Antimicrobial drug efflux pumps in Staphylococcus aureus -- 8.Antimicrobial drug efflux pumps in other Gram-positive bacteria -- 9.Antimicrobial drug efflux pumps in Escherichia coli -- 10.Antimicrobial drug efflux pumps in Salmonella -- 11.Antimicrobial drug efflux pumps in Enterobacter and Klebsiella -- 12.Antimicrobial resistance and drug efflux pumps in Vibrio and Legionella -- 13.Antimicrobial resistance and drug efflux pumps in Acinetobacter -- 14.Antimicrobial drug efflux pumps in Pseudomonas aeruginosa -- 15.Antimicrobial drug efflux pumps in Stenotrophomona maltophilia -- 16.Antimicrobial drug efflux pumps in Burkholderia -- 17.Efflux pumps in Neisseria gonorrhoeae: contributions to antimicrobial resistance and virulence -- 18.Efflux pumps in Campylobacter: key players for antimicrobial resistance and environmental adaption -- 19.Antimicrobial resistance and drug efflux pumps in Helicobacter -- 20.Antimicrobial resistance and drug efflux pumps in Bacteroides -- 21.Efflux pumps in mycobacteria: antimicrobial resistance, physiological functions, and role in pathogenicity -- 22.Antimicrobial drug efflux genes and pumps in bacteria of animal and environmental origin -- 23.Role of plasmid-encoded drug efflux pumps in antimicrobial resistance -- 24.Influence of regulatory RNAs on antimicrobial resistance and efflux mechanisms -- III.Role of drug efflux pumps beyond antimicrobial resistance: natural functions -- 25.The relationship between bacterial multidrug efflux pumps and biofilm formation -- 26.Antimicrobial drug efflux systems as components of bacterial stress responses -- 27.Involvment of antimicrobial drug efflux systems in bacterial fitness and virulence -- IV. Antimicrobial development and efflux pump inhibitors -- 28.Impact of antimicrobial drug efflux pumps on antimicrobial discovery and development -- 29.Antimicrobial drug efflux pump inhibitors -- 30.Multidrug efflux pumps and their inhibitors characterized by computational modeling.

This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.

ISBN: 9783319396583

Standard No.: 10.1007/978-3-319-39658-3doiSubjects--Topical Terms:

644229
Drug resistance in microorganisms.

LC Class. No.: QR177

Dewey Class. No.: 616.9041

Efflux-mediated antimicrobial resistance in bacteria = mechanisms, regulation and clinical implications /
LDR:04809nam a2200313 a 4500 001 867964
003 DE-He213
005 20161109172236.0
006 m d
007 cr nn 008maaau
008 170720s2016 gw s 0 eng d
020 $a 9783319396583 $q (electronic bk.)
020 $a 9783319396569 $q (paper)
024 7 $a 10.1007/978-3-319-39658-3 $2 doi
035 $a 978-3-319-39658-3
040 $a GP $c GP
041 0 $a eng
050 4 $a QR177
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
082 0 4 $a 616.9041 $2 23
090 $a QR177 $b .E27 2016
245 0 0 $a Efflux-mediated antimicrobial resistance in bacteria $h [electronic resource] : $b mechanisms, regulation and clinical implications / $c edited by Xian-Zhi Li, Christopher A. Elkins, Helen I. Zgurskaya.
260 $a Cham : $b Springer International Publishing : $b Imprint: Adis, $c 2016.
300 $a xxi, 848 p. : $b ill., digital ; $c 24 cm.
505 0 $a I-Bacterial drug efflux pumps: structures and transport mechanisms -- 1.Structures and transport mechanisms of RND efflux pumps -- 2.Structural and molecular landscape of MFS and MATE efflux pumps -- 3.Small multidrug resistance efflux pumps -- 4.Structures and transport mechanisms of the ABC efflux pumps -- 5.Multidrug efflux in the context of two-membrane cell envelopes -- II-Bacterial drug efflux pumps in antimicrobial resistance: substrates, regulation and clinical significance -- 6.Antimicrobial resistance in bacteria: an overview of mechanisms and role of drug efflux pumps -- 7.Antimicrobial drug efflux pumps in Staphylococcus aureus -- 8.Antimicrobial drug efflux pumps in other Gram-positive bacteria -- 9.Antimicrobial drug efflux pumps in Escherichia coli -- 10.Antimicrobial drug efflux pumps in Salmonella -- 11.Antimicrobial drug efflux pumps in Enterobacter and Klebsiella -- 12.Antimicrobial resistance and drug efflux pumps in Vibrio and Legionella -- 13.Antimicrobial resistance and drug efflux pumps in Acinetobacter -- 14.Antimicrobial drug efflux pumps in Pseudomonas aeruginosa -- 15.Antimicrobial drug efflux pumps in Stenotrophomona maltophilia -- 16.Antimicrobial drug efflux pumps in Burkholderia -- 17.Efflux pumps in Neisseria gonorrhoeae: contributions to antimicrobial resistance and virulence -- 18.Efflux pumps in Campylobacter: key players for antimicrobial resistance and environmental adaption -- 19.Antimicrobial resistance and drug efflux pumps in Helicobacter -- 20.Antimicrobial resistance and drug efflux pumps in Bacteroides -- 21.Efflux pumps in mycobacteria: antimicrobial resistance, physiological functions, and role in pathogenicity -- 22.Antimicrobial drug efflux genes and pumps in bacteria of animal and environmental origin -- 23.Role of plasmid-encoded drug efflux pumps in antimicrobial resistance -- 24.Influence of regulatory RNAs on antimicrobial resistance and efflux mechanisms -- III.Role of drug efflux pumps beyond antimicrobial resistance: natural functions -- 25.The relationship between bacterial multidrug efflux pumps and biofilm formation -- 26.Antimicrobial drug efflux systems as components of bacterial stress responses -- 27.Involvment of antimicrobial drug efflux systems in bacterial fitness and virulence -- IV. Antimicrobial development and efflux pump inhibitors -- 28.Impact of antimicrobial drug efflux pumps on antimicrobial discovery and development -- 29.Antimicrobial drug efflux pump inhibitors -- 30.Multidrug efflux pumps and their inhibitors characterized by computational modeling.
520 $a This book, written by leading international experts, provides a comprehensive, current examination of transport-mediated antimicrobial resistance. As a particularly powerful mechanism of multidrug resistance, an in-depth examination of efflux pumps is conducted with bacteria of major public health concern including Enterobacteriaceae, Acinetobacter, Neisseria, Pseudomonas, staphylococci, and mycobacteria. The content spans structural biochemistry and transport mechanisms of the major transporter families and considers individual drug efflux systems across various Gram-positive and Gram-negative species. Genomic analysis of efflux pump distribution and their contribution to clinically-relevant resistance are a major focus of the text. Moreover, interplay between drug efflux pumps and other key resistance mechanisms such as intrinsic drug impermeability, inactivation, and target alterations are discussed, as well as their molecular expression-based regulation and physiological functions beyond resistance, involving biofilms, stress response, and pathogenicity. Finally, strategies are addressed to target this drug resistance mechanism with novel antimicrobials or drug inhibitor adjuvants.
650 0 $a Drug resistance in microorganisms. $3 644229
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Drug Resistance. $3 782695
650 2 4 $a Infectious Diseases. $3 668393
700 1 $a Li, Xian-Zhi. $3 1115232
700 1 $a Elkins, Christopher A. $3 1115233
700 1 $a Zgurskaya, Helen I. $3 1115234
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-39658-3
950 $a Biomedical and Life Sciences (Springer-11642)