國立虎尾科技大學 |

Basic research and clinical aspects of adamantinomatous craniopharyngioma

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Basic research and clinical aspects of adamantinomatous craniopharyngioma/ edited by Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou.
other author:	Martinez-Barbera, Juan Pedro.
Published:	Cham :Springer International Publishing : : 2017.,
Description:	xii, 220 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Brain - Tumors. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-51890-9
ISBN:	9783319518909

Basic research and clinical aspects of adamantinomatous craniopharyngioma
Basic research and clinical aspects of adamantinomatous craniopharyngioma[electronic resource] /edited by Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou. - Cham :Springer International Publishing :2017. - xii, 220 p. :ill., digital ;24 cm.

Pathogenesis of human ACP -- Transcriptomic and Genomic Analyses of Human Craniopharyngioma -- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma -- Clinical Diagnosis of Human ACP -- Endocrine Deficits in Patients with Human Craniopharyngioma -- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients -- Radiology and Radiotherapy of Craniopharyngioma -- Surgical Treatment of Human ACP -- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden -- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma.

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs) ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.

ISBN: 9783319518909

Standard No.: 10.1007/978-3-319-51890-9doiSubjects--Topical Terms:

769244
Brain
--Tumors.

LC Class. No.: RC280.B7

Dewey Class. No.: 618.9299481

Basic research and clinical aspects of adamantinomatous craniopharyngioma
LDR:03203nam a2200313 a 4500 001 884953
003 DE-He213
005 20170420182813.0
006 m d
007 cr nn 008maaau
008 180530s2017 gw s 0 eng d
020 $a 9783319518909 $q (electronic bk.)
020 $a 9783319518886 $q (paper)
024 7 $a 10.1007/978-3-319-51890-9 $2 doi
035 $a 978-3-319-51890-9
040 $a GP $c GP
041 0 $a eng
050 4 $a RC280.B7
072 7 $a MJG $2 bicssc
072 7 $a MED027000 $2 bisacsh
082 0 4 $a 618.9299481 $2 23
090 $a RC280.B7 $b B311 2017
245 0 0 $a Basic research and clinical aspects of adamantinomatous craniopharyngioma $h [electronic resource] / $c edited by Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou.
260 $a Cham : $c 2017. $b Springer International Publishing : $b Imprint: Springer,
300 $a xii, 220 p. : $b ill., digital ; $c 24 cm.
505 0 $a Pathogenesis of human ACP -- Transcriptomic and Genomic Analyses of Human Craniopharyngioma -- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma -- Clinical Diagnosis of Human ACP -- Endocrine Deficits in Patients with Human Craniopharyngioma -- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients -- Radiology and Radiotherapy of Craniopharyngioma -- Surgical Treatment of Human ACP -- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden -- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma.
520 $a This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs) ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
650 0 $a Brain $x Tumors. $3 769244
650 0 $a Skull $x Tumors. $3 1141798
650 0 $a Cancer in children. $3 644771
650 1 4 $a Medicine & Public Health. $3 593949
650 2 4 $a Endocrinology. $3 645497
650 2 4 $a Cancer Research. $3 668358
650 2 4 $a Stem Cells. $3 782732
700 1 $a Martinez-Barbera, Juan Pedro. $3 1141796
700 1 $a Lilian Andoniadou, Cynthia Lilian. $3 1141797
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-51890-9
950 $a Medicine (Springer-11650)