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Impact of survivin acetylation on its biological function

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Impact of survivin acetylation on its biological function/ by David Dannheisig.
Author:	Dannheisig, David.
Published:	Wiesbaden :Springer Fachmedien Wiesbaden : : 2017.,
Description:	xxiii, 104 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Lysine. -
Online resource:	http://dx.doi.org/10.1007/978-3-658-18623-4
ISBN:	9783658186234

Impact of survivin acetylation on its biological function
Dannheisig, David.

Impact of survivin acetylation on its biological function[electronic resource] /by David Dannheisig. - Wiesbaden :Springer Fachmedien Wiesbaden :2017. - xxiii, 104 p. :ill. (some col.), digital ;24 cm. - BestMasters. - BestMasters..

Apoptosis - The Programmed Suicide -- Cancer - The Enemy Inside -- Nucleocytoplasmic Transport- Cellular Navigation -- Biological Function of Survivin -- Protein modification - Make-Up for Proteins -- Cell cycle - Virchow's Heritage.

In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies. Contents Apoptosis - The Programmed Suicide Cancer - The Enemy Inside Nucleocytoplasmic Transport- Cellular Navigation Biological Function of Survivin Protein modification - Make-Up for Proteins Cell cycle - Virchow's Heritage Target Groups Lecturers, students and researchers in the biological-medical sector Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies The Author David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.

ISBN: 9783658186234

Standard No.: 10.1007/978-3-658-18623-4doiSubjects--Topical Terms:

1172687
Lysine.

LC Class. No.: QP171

Dewey Class. No.: 572.6519

Impact of survivin acetylation on its biological function
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