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Localized surface functionalization with atmospheric-pressure microplasma jet for cell-on-a-chip applications.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Localized surface functionalization with atmospheric-pressure microplasma jet for cell-on-a-chip applications./
Author:	Wang, Chengyang.
Description:	1 online resource (144 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-05(E), Section: B.
Contained By:	Dissertation Abstracts International78-05B(E).
Subject:	Mechanical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9781369286502

Localized surface functionalization with atmospheric-pressure microplasma jet for cell-on-a-chip applications.
Wang, Chengyang.

Localized surface functionalization with atmospheric-pressure microplasma jet for cell-on-a-chip applications. - 1 online resource (144 pages)

Source: Dissertation Abstracts International, Volume: 78-05(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

Surface properties of biopolymers are crucial for providing topographical and chemical cues to affect cellular behaviors, such as attachment, spreading, viability, proliferation, and differentiation. As an effective surface modification technique, plasma treatment is often applied to enhance surface wettability, adhesion, and biocompatibility of polymers. This study concentrates on developing technical platforms, experimental procedures, and computational-statistical models to manipulate and control the cellular functions on specifically modified polymer surfaces. A novel freeform microplasma-generated maskless surface patterning process was developed to create spatially defined topological and chemical features on biopolymer surface. Global and localized plasma functionalization was performed on polycaprolactone (PCL) samples to introduce biophysical, biochemical, biological and structural cues to enhance cellular response including attachment, proliferation and differentiation. A plasma computational-statistical model was developed to predict the changes in biopolymer surface physicochemical properties following the oxygen based plasma surface functionalization. Furthermore, an integrated system including localized plasma functionalization was specifically designed for the development of biologically inspired devices. The capabilities, benefits, and challenges of the integrated multifunctional biofabrication system to develop cell-on-a-chip device were also illustrated. The objective of this thesis is to contribute scientific and engineering knowledge to the utilization of plasma chemistry to enhance surface functionalization, development of an engineering model for local plasma treatment, and integration of biofabrication processes to assemble cell-on-a-chip devices.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369286502Subjects--Topical Terms:

557493
Mechanical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Localized surface functionalization with atmospheric-pressure microplasma jet for cell-on-a-chip applications.
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504 $a Includes bibliographical references
520 $a Surface properties of biopolymers are crucial for providing topographical and chemical cues to affect cellular behaviors, such as attachment, spreading, viability, proliferation, and differentiation. As an effective surface modification technique, plasma treatment is often applied to enhance surface wettability, adhesion, and biocompatibility of polymers. This study concentrates on developing technical platforms, experimental procedures, and computational-statistical models to manipulate and control the cellular functions on specifically modified polymer surfaces. A novel freeform microplasma-generated maskless surface patterning process was developed to create spatially defined topological and chemical features on biopolymer surface. Global and localized plasma functionalization was performed on polycaprolactone (PCL) samples to introduce biophysical, biochemical, biological and structural cues to enhance cellular response including attachment, proliferation and differentiation. A plasma computational-statistical model was developed to predict the changes in biopolymer surface physicochemical properties following the oxygen based plasma surface functionalization. Furthermore, an integrated system including localized plasma functionalization was specifically designed for the development of biologically inspired devices. The capabilities, benefits, and challenges of the integrated multifunctional biofabrication system to develop cell-on-a-chip device were also illustrated. The objective of this thesis is to contribute scientific and engineering knowledge to the utilization of plasma chemistry to enhance surface functionalization, development of an engineering model for local plasma treatment, and integration of biofabrication processes to assemble cell-on-a-chip devices.
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538 $a Mode of access: World Wide Web
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