國立虎尾科技大學 |

Control theoretic analysis of human brain networks.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Control theoretic analysis of human brain networks./
Author:	Gu, Shi.
Description:	1 online resource (181 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 77-12(E), Section: B.
Contained By:	Dissertation Abstracts International77-12B(E).
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9781339929002

Control theoretic analysis of human brain networks.
Gu, Shi.

Control theoretic analysis of human brain networks. - 1 online resource (181 pages)

Source: Dissertation Abstracts International, Volume: 77-12(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

The brain is a complex system with complicated structures and entangled dynamics. Among the various approaches to investigating the brain's mechanics, the graphical method provides a successful framework for understanding the topology of both the structural and functional networks, and discovering efficient diagnostic biomarkers for cognitive behaviors, brain disorders and diseases. Yet it cannot explain how the structure affects the functionality and how the brain tunes its transition among multiple states to manipulate the cognitive control. In my dissertation, I propose a novel framework of modeling the mechanics of the cognitive control, which involves in applying control theory to analyzing the brain networks and conceptually connecting the cognitive control with the engineering control. First, I examine the energy distribution among different states via combining the energetic and structural constraints of the brain's state transition in a free energy model, where the interaction between regions is explicitly informed by structural connectivity. This work enables the possibility of achieving a whole view of the brain's energy landscape and preliminarily indicates the feasibility of control theory to model the dynamics of cognitive control. In the following work, I exploit the network control theory to address two questions about how the large-scale circuitry of the human brain constrains its dynamics. First, is the human brain theoretically controllable? Second, which areas of the brain are most influential in constraining or facilitating changes in brain state trajectories? Further, I seek to examine the structural effect on the control actions through solving the optimal control problem under different boundary conditions. I quantify the efficiency of regions in terms of the energy cost for the brain state transition from the default mode to task modes. This analysis is extended to the perturbation analysis of trajectories and is applied to the comparison between the group with mild traumatic brain injury(mTBI) and the healthy group. My research is the first to demonstrate how control theory can be used to analyze human brain networks.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781339929002Subjects--Topical Terms:

593561
Neurosciences.
Index Terms--Genre/Form:

554714
Electronic books.

Control theoretic analysis of human brain networks.
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245 1 0 $a Control theoretic analysis of human brain networks.
264 0 $c 2016
300 $a 1 online resource (181 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 77-12(E), Section: B.
500 $a Adviser: Danielle S. Bassett.
502 $a Thesis (Ph.D.) $c University of Pennsylvania $d 2016.
504 $a Includes bibliographical references
520 $a The brain is a complex system with complicated structures and entangled dynamics. Among the various approaches to investigating the brain's mechanics, the graphical method provides a successful framework for understanding the topology of both the structural and functional networks, and discovering efficient diagnostic biomarkers for cognitive behaviors, brain disorders and diseases. Yet it cannot explain how the structure affects the functionality and how the brain tunes its transition among multiple states to manipulate the cognitive control. In my dissertation, I propose a novel framework of modeling the mechanics of the cognitive control, which involves in applying control theory to analyzing the brain networks and conceptually connecting the cognitive control with the engineering control. First, I examine the energy distribution among different states via combining the energetic and structural constraints of the brain's state transition in a free energy model, where the interaction between regions is explicitly informed by structural connectivity. This work enables the possibility of achieving a whole view of the brain's energy landscape and preliminarily indicates the feasibility of control theory to model the dynamics of cognitive control. In the following work, I exploit the network control theory to address two questions about how the large-scale circuitry of the human brain constrains its dynamics. First, is the human brain theoretically controllable? Second, which areas of the brain are most influential in constraining or facilitating changes in brain state trajectories? Further, I seek to examine the structural effect on the control actions through solving the optimal control problem under different boundary conditions. I quantify the efficiency of regions in terms of the energy cost for the brain state transition from the default mode to task modes. This analysis is extended to the perturbation analysis of trajectories and is applied to the comparison between the group with mild traumatic brain injury(mTBI) and the healthy group. My research is the first to demonstrate how control theory can be used to analyze human brain networks.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 593561
650 4 $a Applied mathematics. $3 1069907
650 4 $a Biomedical engineering. $3 588770
655 7 $a Electronic books. $2 local $3 554714
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710 2 $a University of Pennsylvania. $b Applied Mathematics and Computational Science. $3 1180480
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10134967 $z click for full text (PQDT)