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Alternans, ephaptic coupling and their relation to ventricular arrhythmias.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Alternans, ephaptic coupling and their relation to ventricular arrhythmias./
Author:	Wei, Ning.
Description:	1 online resource (90 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 77-11(E), Section: B.
Contained By:	Dissertation Abstracts International77-11B(E).
Subject:	Applied mathematics. -
Online resource:	click for full text (PQDT)
ISBN:	9781339972770

Alternans, ephaptic coupling and their relation to ventricular arrhythmias.
Wei, Ning.

Alternans, ephaptic coupling and their relation to ventricular arrhythmias. - 1 online resource (90 pages)

Source: Dissertation Abstracts International, Volume: 77-11(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

The heart functions as a mechanical pump that propels blood through the circulatory system. Blood flows from the body into the right atrium, and then into the right ventricle where it gets pumped into the lungs through the pulmonary artery. Blood gets oxygenated in the lungs, flows into the left atrium, and then into the left ventricle where it gets pumped through the aorta to different organs of the body. Ventricular fibrillation (VF), identified as disorganized and ineffective quiver of the ventricles, is the most serious ventricular arrhythmias. When VF occurs, the heart is unable to pump blood. Sudden cardiac arrest follows. About 220,000 deaths from heart attacks in the United States each year are thought to be caused by VF.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781339972770Subjects--Topical Terms:

1069907
Applied mathematics.
Index Terms--Genre/Form:

554714
Electronic books.

Alternans, ephaptic coupling and their relation to ventricular arrhythmias.
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035 $a AAI10141954
040 $a MiAaPQ $b eng $c MiAaPQ
099 $a TUL $f hyy $c available through World Wide Web
100 1 $a Wei, Ning. $3 1180492
245 1 0 $a Alternans, ephaptic coupling and their relation to ventricular arrhythmias.
264 0 $c 2016
300 $a 1 online resource (90 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertation Abstracts International, Volume: 77-11(E), Section: B.
500 $a Advisers: Yoichiro Mori; Alena Talkachova.
502 $a Thesis (Ph.D.) $c University of Minnesota $d 2016.
504 $a Includes bibliographical references
520 $a The heart functions as a mechanical pump that propels blood through the circulatory system. Blood flows from the body into the right atrium, and then into the right ventricle where it gets pumped into the lungs through the pulmonary artery. Blood gets oxygenated in the lungs, flows into the left atrium, and then into the left ventricle where it gets pumped through the aorta to different organs of the body. Ventricular fibrillation (VF), identified as disorganized and ineffective quiver of the ventricles, is the most serious ventricular arrhythmias. When VF occurs, the heart is unable to pump blood. Sudden cardiac arrest follows. About 220,000 deaths from heart attacks in the United States each year are thought to be caused by VF.
520 $a Alternans, a periodic beat-to-beat short-long alternation in action potential duration (APD), is considered to be a precursor of VF. In extended cardiac tissue, electrical alternans can be either spatially concordant (SCA, all cells oscillate in phase) or spatially discordant (SDA, cells in different regions oscillate out of phase). SDA gives rise to an increase in the spatial dispersion of repolarization, which is thought to be proarrhythmic. In this dissertation, I use a mapping model with two beats of memory, a simple but powerful tool to study cardiac dynamics and their relation to VF at the level of single cell and a spatially coupled cell strand.
520 $a Ventricular myocytes are connected electrically by gap junction channels formed mainly by connexin 43 (Cx43) and, to a smaller extent, Cx45. Decreased and heterogeneous expression of Cx43 is a common feature in animal heart failure models. Ephaptic coupling is an electric field mechanism of propagation. It relies on the presence of narrow cleft space between neighboring cells, which is resistively connected to the extracellular space. Emerging evidence suggests a more active role for ephaptic coupling in mediating intercellular electrical communication when gap junctions are reduced in a homogeneous manner. Here, I explore the effect of ephaptic coupling when Cx43 expression is reduced in a heterogeneous fashion. For this purpose, I use a physiologically detailed ionic channel model with their gating kinetics applied in a two dimensional tissue model of electrically coupled cardiac cells.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Applied mathematics. $3 1069907
650 4 $a Physiology. $3 673386
655 7 $a Electronic books. $2 local $3 554714
690 $a 0364
690 $a 0719
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Minnesota. $b Mathematics. $3 1180493
773 0 $t Dissertation Abstracts International $g 77-11B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10141954 $z click for full text (PQDT)