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Spontaneous Oscillation and Fluid-Structure Interaction of Cilia.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Spontaneous Oscillation and Fluid-Structure Interaction of Cilia./
Author:	Han, Jihun.
Description:	1 online resource (116 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.
Contained By:	Dissertation Abstracts International79-02B(E).
Subject:	Mathematics. -
Online resource:	click for full text (PQDT)
ISBN:	9780355406870

Spontaneous Oscillation and Fluid-Structure Interaction of Cilia.
Han, Jihun.

Spontaneous Oscillation and Fluid-Structure Interaction of Cilia. - 1 online resource (116 pages)

Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

The exact mechanism to orchestrate the action of hundreds of dynein motor proteins to generate wave-like ciliary beating remains puzzling and has fascinated many scientists. We present a three-dimensional model of a cilium and the simulation of its beating in a fluid environment. The model cilium obeys a simple geometric constraint that arises naturally from the microscopic structure of a real cilium. This constraint allows us to determine the whole three dimensional structure at any instant in terms of the configuration of a single space curve. The tensions of active links which model the dynein motor proteins follow a postulated dynamical law, and, together with the passive elasticity of microtubules, this dynamical law is responsible for the ciliary motions. In particular, our postulated tension dynamics lead to the instability of a symmetrical steady state in which the cilium is straight and its active links are under equal tensions. The result of this instability is a stable, wave-like, limit-cycle oscillation. We have also investigated the fluid-structure interaction of cilia using the immersed boundary (IB) method. In this setting we see not only coordination within a single cilium, but also coordinated motion in which multiple cilia in an array organize their beating to pump fluid, in particular, by breaking phase synchronization.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355406870Subjects--Topical Terms:

527692
Mathematics.
Index Terms--Genre/Form:

554714
Electronic books.

Spontaneous Oscillation and Fluid-Structure Interaction of Cilia.
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100 1 $a Han, Jihun. $3 1180641
245 1 0 $a Spontaneous Oscillation and Fluid-Structure Interaction of Cilia.
264 0 $c 2017
300 $a 1 online resource (116 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
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500 $a Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.
500 $a Adviser: Charles S. Peskin.
502 $a Thesis (Ph.D.) $c New York University $d 2017.
504 $a Includes bibliographical references
520 $a The exact mechanism to orchestrate the action of hundreds of dynein motor proteins to generate wave-like ciliary beating remains puzzling and has fascinated many scientists. We present a three-dimensional model of a cilium and the simulation of its beating in a fluid environment. The model cilium obeys a simple geometric constraint that arises naturally from the microscopic structure of a real cilium. This constraint allows us to determine the whole three dimensional structure at any instant in terms of the configuration of a single space curve. The tensions of active links which model the dynein motor proteins follow a postulated dynamical law, and, together with the passive elasticity of microtubules, this dynamical law is responsible for the ciliary motions. In particular, our postulated tension dynamics lead to the instability of a symmetrical steady state in which the cilium is straight and its active links are under equal tensions. The result of this instability is a stable, wave-like, limit-cycle oscillation. We have also investigated the fluid-structure interaction of cilia using the immersed boundary (IB) method. In this setting we see not only coordination within a single cilium, but also coordinated motion in which multiple cilia in an array organize their beating to pump fluid, in particular, by breaking phase synchronization.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Mathematics. $3 527692
655 7 $a Electronic books. $2 local $3 554714
690 $a 0405
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a New York University. $b Mathematics. $3 1180487
773 0 $t Dissertation Abstracts International $g 79-02B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10261730 $z click for full text (PQDT)