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A Novel Multi-Scale Model of Time-Scale Integration for Modeling the Hemodynamics of the Cardiovascular System.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	A Novel Multi-Scale Model of Time-Scale Integration for Modeling the Hemodynamics of the Cardiovascular System./
Author:	Leon, Jessica Caitlin.
Description:	1 online resource (67 pages)
Notes:	Source: Masters Abstracts International, Volume: 57-02.
Contained By:	Masters Abstracts International57-02(E).
Subject:	Bioengineering. -
Online resource:	click for full text (PQDT)
ISBN:	9780355333817

A Novel Multi-Scale Model of Time-Scale Integration for Modeling the Hemodynamics of the Cardiovascular System.
Leon, Jessica Caitlin.

A Novel Multi-Scale Model of Time-Scale Integration for Modeling the Hemodynamics of the Cardiovascular System. - 1 online resource (67 pages)

Source: Masters Abstracts International, Volume: 57-02.

Thesis (M.S.)

Includes bibliographical references

The cardiovascular system is regulated through numerous control systems, which operate on various time scales. The baroreflex operates on the scale of seconds to minutes, responding to acute changes in pressure by altering heart rate, heart contractility, and blood vessel diameter. Blood volume control operates on a time scale of minutes to hours, in which the kidneys regulate blood pressure by means of blood plasma osmolarity and volume in the circulatory system. When pressure is altered on a longer time scale of days to years, growth and remodeling occur in the heart and blood vessel walls.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355333817Subjects--Topical Terms:

598252
Bioengineering.
Index Terms--Genre/Form:

554714
Electronic books.

A Novel Multi-Scale Model of Time-Scale Integration for Modeling the Hemodynamics of the Cardiovascular System.
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100 1 $a Leon, Jessica Caitlin. $3 1180909
245 1 2 $a A Novel Multi-Scale Model of Time-Scale Integration for Modeling the Hemodynamics of the Cardiovascular System.
264 0 $c 2017
300 $a 1 online resource (67 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Masters Abstracts International, Volume: 57-02.
500 $a Adviser: Andrew D. McCulloch; Jeffery H. Omens.
502 $a Thesis (M.S.) $c University of California, San Diego $d 2017.
504 $a Includes bibliographical references
520 $a The cardiovascular system is regulated through numerous control systems, which operate on various time scales. The baroreflex operates on the scale of seconds to minutes, responding to acute changes in pressure by altering heart rate, heart contractility, and blood vessel diameter. Blood volume control operates on a time scale of minutes to hours, in which the kidneys regulate blood pressure by means of blood plasma osmolarity and volume in the circulatory system. When pressure is altered on a longer time scale of days to years, growth and remodeling occur in the heart and blood vessel walls.
520 $a In this thesis, a multi-scale model was created to improve the capacity for study of the summed or individual effects of different time scales. This time scale consideration resulted in a more physiological approach to modeling the cardiovascular system than previous models. The time scales modeled were an acute seconds-to-minutes scale, during which the baroreflex acts, and a minutes-to-hours scale during which blood volume control occurs. The model was then optimized to allow for future coupling to computationally expensive growth and remodeling models. Arterial pressure regulation was demonstrated in both normal conditions and the pathophysiological condition of aortic valve disease. The work of this thesis successfully reproduced the local effects of the disease, and demonstrated the physiologic response on multiple time scales to the reduction in arterial pressure at an aortic stenosis.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Bioengineering. $3 598252
650 4 $a Mathematics. $3 527692
650 4 $a Engineering. $3 561152
655 7 $a Electronic books. $2 local $3 554714
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710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, San Diego. $b Bioengineering. $3 1180910
773 0 $t Masters Abstracts International $g 57-02(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10623450 $z click for full text (PQDT)