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First Trimester Use of Artemisinin-Based Combination Therapy and Risk of Low Birth Weight.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	First Trimester Use of Artemisinin-Based Combination Therapy and Risk of Low Birth Weight./
Author:	Augusto, Orvalho Joaquim.
Description:	1 online resource (32 pages)
Notes:	Source: Masters Abstracts International, Volume: 56-03.
Contained By:	Masters Abstracts International56-03(E).
Subject:	Public health. -
Online resource:	click for full text (PQDT)
ISBN:	9781369693539

First Trimester Use of Artemisinin-Based Combination Therapy and Risk of Low Birth Weight.
Augusto, Orvalho Joaquim.

First Trimester Use of Artemisinin-Based Combination Therapy and Risk of Low Birth Weight. - 1 online resource (32 pages)

Source: Masters Abstracts International, Volume: 56-03.

Thesis (M.P.H.)

Includes bibliographical references

Introduction: There is a lack of sufficient evidence on the safety of use of artemisinin-based combination therapies (ACT) among pregnant women, especially during early pregnancy. We determined the association between exposure to ACT during the first trimester of pregnancy and occurrence of low birth weight (LBW), and small for gestational age (SGA) among the offspring of pregnant women.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369693539Subjects--Topical Terms:

560998
Public health.
Index Terms--Genre/Form:

554714
Electronic books.

First Trimester Use of Artemisinin-Based Combination Therapy and Risk of Low Birth Weight.
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020 $a 9781369693539
035 $a (MiAaPQ)AAI10257573
035 $a (MiAaPQ)washington:16834
035 $a AAI10257573
040 $a MiAaPQ $b eng $c MiAaPQ
099 $a TUL $f hyy $c available through World Wide Web
100 1 $a Augusto, Orvalho Joaquim. $3 1181283
245 1 0 $a First Trimester Use of Artemisinin-Based Combination Therapy and Risk of Low Birth Weight.
264 0 $c 2017
300 $a 1 online resource (32 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Masters Abstracts International, Volume: 56-03.
500 $a Adviser: Andy Stergachis.
502 $a Thesis (M.P.H.) $c University of Washington $d 2017.
504 $a Includes bibliographical references
520 $a Introduction: There is a lack of sufficient evidence on the safety of use of artemisinin-based combination therapies (ACT) among pregnant women, especially during early pregnancy. We determined the association between exposure to ACT during the first trimester of pregnancy and occurrence of low birth weight (LBW), and small for gestational age (SGA) among the offspring of pregnant women.
520 $a Methods: We performed a secondary analysis of data from a prospective cohort study of pregnant women recruited at three health and demographic surveillance system (HDSS) sites in the sub-Saharan African countries of Mozambique, Burkina Faso and Kenya. Data from the HDSS allowed earlier pregnancy identification and linkage and tracking of pregnancy outcomes to determine birth weight and gestational age at delivery. Exposure to any antimalarials was ascertained through a combination of data collected from clinic registers, prescription records and self-reported usage by the women.
520 $a Results: There was no difference in the pooled prevalence of LBW among children born to pregnant women who were exposed to quinine, ACT and had no exposure to antimalarials, 21.0%, 11.3% and 10.2%, respectively. Children whose mothers had exposure to ACTs during the first trimester had 21% lower occurrence of LBW when compared to children born to mothers exposed to ACTs in second or third trimester, this difference was not statistical significant (95%CI: -7-49%).
520 $a Conclusion: ACT exposure during the first trimester was not associated with an increased risk of LBW. Our findings support the use of ACT for treatment of malaria during the first trimester of pregnancy.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Public health. $3 560998
655 7 $a Electronic books. $2 local $3 554714
690 $a 0573
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Washington. $b Global Health. $3 1181284
773 0 $t Masters Abstracts International $g 56-03(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10257573 $z click for full text (PQDT)