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Influence of Aging and Lifelong Exercise on Skeletal Muscle Inflammation.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Influence of Aging and Lifelong Exercise on Skeletal Muscle Inflammation./
作者:	Lavin, Kaleen Marie.
面頁冊數:	1 online resource (207 pages)
附註:	Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.
Contained By:	Dissertation Abstracts International78-12B(E).
標題:	Physiology. -
電子資源:	click for full text (PQDT)
ISBN:	9780355103779

Influence of Aging and Lifelong Exercise on Skeletal Muscle Inflammation.
Lavin, Kaleen Marie.

Influence of Aging and Lifelong Exercise on Skeletal Muscle Inflammation. - 1 online resource (207 pages)

Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

Age-associated chronic basal inflammation negatively impacts muscle mass and adaptability, but exercise training may combat this through its anti-inflammatory effects. This investigation assessed basal and acute exercise-induced inflammation in three male cohorts: young exercisers (YE, n=10, 25+/-1 y, VO 2max: 52.9+/-2.5 mL/kg/min, quadriceps volume: 1264+/-71 cm 3), old healthy non-exercisers (OH, n=10, 75+/-1 y, VO2 max: 21.8+/-1.3 mL/kg/min, quadriceps volume: 868+/-58 cm 3), and lifelong exercisers with a 53+/-1 y aerobic training history (LLE, n=21, 74+/-1 y, VO2max: 34.0+/-1.3 mL/kg/min, quadriceps volume: 1050+/-38 cm3). Resting serum IL-6, TNF-alpha, CRP, and IGF-1 were measured. Vastus lateralis muscle biopsies were obtained at rest and 4h after acute resistance exercise (3 x 10 reps at 70% 1RM) to assess gene expression of cytokines (IL-6, TNF-alpha, IL-1beta, IL-10, IL-4, IL-1Ra, TGF-beta), chemokines (IL-8, MCP-1), cycylooxygenase enzymes (COX-1, COX-2), prostaglandin E2 synthases (mPGES-1, cPGES) and receptors (EP3-4), and macrophage markers (CD16b, CD163). Aging led to higher (P≤0.05) circulating IL-6 in OH, which was attenuated (P≤0.10) in LLE. The older cohorts had higher ( P≤0.05) basal COX-1, mPGES-1, and CD163 expression. However, LLE had higher basal IL-10 (P≤0.05 vs. YE), TNF-alpha, TGF-beta, and EP4 (P≤0.05 vs. OH). Exercise increased expression of TNF-alpha, TGF-beta, IL-8 (P≤0.05), and COX-1 ( P≤0.10) in only OH. LLE had lower post-exercise expression of IL-10 (P≤0.10), mPGES-1, and EP3 (P≤0.05) than YE. COX-2, EP4, CD16b, (P≤0.05) and CD163 ( P≤0.10) increased after exercise across all groups. In summary, aging led to a pro-inflammatory profile within blood and muscle. Lifelong exercise partially prevented this effect, while generally preserving the acute inflammatory response to exercise. Lifelong exercise promotes an anti-inflammatory muscle environment, which may positively impact muscle health throughout aging.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355103779Subjects--Topical Terms:

673386
Physiology.
Index Terms--Genre/Form:

554714
Electronic books.

Influence of Aging and Lifelong Exercise on Skeletal Muscle Inflammation.
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500 $a Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.
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504 $a Includes bibliographical references
520 $a Age-associated chronic basal inflammation negatively impacts muscle mass and adaptability, but exercise training may combat this through its anti-inflammatory effects. This investigation assessed basal and acute exercise-induced inflammation in three male cohorts: young exercisers (YE, n=10, 25+/-1 y, VO 2max: 52.9+/-2.5 mL/kg/min, quadriceps volume: 1264+/-71 cm 3), old healthy non-exercisers (OH, n=10, 75+/-1 y, VO2 max: 21.8+/-1.3 mL/kg/min, quadriceps volume: 868+/-58 cm 3), and lifelong exercisers with a 53+/-1 y aerobic training history (LLE, n=21, 74+/-1 y, VO2max: 34.0+/-1.3 mL/kg/min, quadriceps volume: 1050+/-38 cm3). Resting serum IL-6, TNF-alpha, CRP, and IGF-1 were measured. Vastus lateralis muscle biopsies were obtained at rest and 4h after acute resistance exercise (3 x 10 reps at 70% 1RM) to assess gene expression of cytokines (IL-6, TNF-alpha, IL-1beta, IL-10, IL-4, IL-1Ra, TGF-beta), chemokines (IL-8, MCP-1), cycylooxygenase enzymes (COX-1, COX-2), prostaglandin E2 synthases (mPGES-1, cPGES) and receptors (EP3-4), and macrophage markers (CD16b, CD163). Aging led to higher (P≤0.05) circulating IL-6 in OH, which was attenuated (P≤0.10) in LLE. The older cohorts had higher ( P≤0.05) basal COX-1, mPGES-1, and CD163 expression. However, LLE had higher basal IL-10 (P≤0.05 vs. YE), TNF-alpha, TGF-beta, and EP4 (P≤0.05 vs. OH). Exercise increased expression of TNF-alpha, TGF-beta, IL-8 (P≤0.05), and COX-1 ( P≤0.10) in only OH. LLE had lower post-exercise expression of IL-10 (P≤0.10), mPGES-1, and EP3 (P≤0.05) than YE. COX-2, EP4, CD16b, (P≤0.05) and CD163 ( P≤0.10) increased after exercise across all groups. In summary, aging led to a pro-inflammatory profile within blood and muscle. Lifelong exercise partially prevented this effect, while generally preserving the acute inflammatory response to exercise. Lifelong exercise promotes an anti-inflammatory muscle environment, which may positively impact muscle health throughout aging.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
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650 4 $a Kinesiology. $3 721210
650 4 $a Aging. $3 559847
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