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The Effects of Melatonin on Circadian and Developmental Gene Expression in Danio rerio.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	The Effects of Melatonin on Circadian and Developmental Gene Expression in Danio rerio./
作者:	Krznarich, Jennifer L.
面頁冊數:	1 online resource (91 pages)
附註:	Source: Masters Abstracts International, Volume: 57-01.
Contained By:	Masters Abstracts International57-01(E).
標題:	Developmental biology. -
電子資源:	click for full text (PQDT)
ISBN:	9780355415896

The Effects of Melatonin on Circadian and Developmental Gene Expression in Danio rerio.
Krznarich, Jennifer L.

The Effects of Melatonin on Circadian and Developmental Gene Expression in Danio rerio. - 1 online resource (91 pages)

Source: Masters Abstracts International, Volume: 57-01.

Thesis (M.S.)

Includes bibliographical references

The circadian clock is an intracellular transcriptional-translational feedback loop that drives circadian rhythms. In zebrafish, these circadian clocks are found throughout the body and can be directly entrained by light. Melatonin synthesis begins early in zebrafish development (&sim;22 hours post fertilization) and nocturnal melatonin biosynthesis is one of the first signs of the circadian system. Our data suggest that melatonin does not play a role in establishment of daily gene expression rhythms in developing zebrafish. We found that melatonin or a melatonin receptor antagonist did not impact expression of circadian clock-controlled genes (irbp and aanat2) or genes encoding components of the circadian clock ( period3 and clock1). However, consistent with research by others suggesting that melatonin accelerates development, our preliminary work suggests that melatonin may advance gene expression onset of dbx2 and irbp in the first 24 hours of development.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355415896Subjects--Topical Terms:

669036
Developmental biology.
Index Terms--Genre/Form:

554714
Electronic books.

The Effects of Melatonin on Circadian and Developmental Gene Expression in Danio rerio.
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245 1 4 $a The Effects of Melatonin on Circadian and Developmental Gene Expression in Danio rerio.
264 0 $c 2017
300 $a 1 online resource (91 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Masters Abstracts International, Volume: 57-01.
500 $a Adviser: Jennifer Liang.
502 $a Thesis (M.S.) $c University of Minnesota $d 2017.
504 $a Includes bibliographical references
520 $a The circadian clock is an intracellular transcriptional-translational feedback loop that drives circadian rhythms. In zebrafish, these circadian clocks are found throughout the body and can be directly entrained by light. Melatonin synthesis begins early in zebrafish development (&sim;22 hours post fertilization) and nocturnal melatonin biosynthesis is one of the first signs of the circadian system. Our data suggest that melatonin does not play a role in establishment of daily gene expression rhythms in developing zebrafish. We found that melatonin or a melatonin receptor antagonist did not impact expression of circadian clock-controlled genes (irbp and aanat2) or genes encoding components of the circadian clock ( period3 and clock1). However, consistent with research by others suggesting that melatonin accelerates development, our preliminary work suggests that melatonin may advance gene expression onset of dbx2 and irbp in the first 24 hours of development.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Developmental biology. $3 669036
655 7 $a Electronic books. $2 local $3 554714
690 $a 0758
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Minnesota. $b Biological Science. $3 1182771
773 0 $t Masters Abstracts International $g 57-01(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10624240 $z click for full text (PQDT)