國立虎尾科技大學 |

Multilayered Magnetic Nanoparticles Fabricated by Nanoimprint Lithography for Magnetomechanical Treatment of Cancer.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Multilayered Magnetic Nanoparticles Fabricated by Nanoimprint Lithography for Magnetomechanical Treatment of Cancer./
作者:	Kwon, Byung Seok.
面頁冊數:	1 online resource (109 pages)
附註:	Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
Contained By:	Dissertation Abstracts International79-01B(E).
標題:	Materials science. -
電子資源:	click for full text (PQDT)
ISBN:	9780355119923

Multilayered Magnetic Nanoparticles Fabricated by Nanoimprint Lithography for Magnetomechanical Treatment of Cancer.
Kwon, Byung Seok.

Multilayered Magnetic Nanoparticles Fabricated by Nanoimprint Lithography for Magnetomechanical Treatment of Cancer. - 1 online resource (109 pages)

Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

Fe3O4-magetite nanoparticles have received wide interest as prominent agents for various biomedical applications, ranging from target-specific cancer treatment, gene therapy, and Magnetic Particle Imaging (MPI). However, Fe3O4-magnetite nanoparticles, synthesized by chemical methods beyond a certain size, present challenges in controlling size distribution and shape. Similarly, Fe3O 4-magnetite nanoparticles fabricated by conventional top-down lithographic methods present difficulty of controlling defects and lead to agglomeration due to large size. In order to overcome the difficulties associated with the conventional chemical and top-down lithographic methods, it is critical to develop a fabrication method which produces homogeneous nanoparticles in large quantities with the control of size, defects, and structure.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355119923Subjects--Topical Terms:

557839
Materials science.
Index Terms--Genre/Form:

554714
Electronic books.

Multilayered Magnetic Nanoparticles Fabricated by Nanoimprint Lithography for Magnetomechanical Treatment of Cancer.
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100 1 $a Kwon, Byung Seok. $3 1182929
245 1 0 $a Multilayered Magnetic Nanoparticles Fabricated by Nanoimprint Lithography for Magnetomechanical Treatment of Cancer.
264 0 $c 2017
300 $a 1 online resource (109 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
500 $a Adviser: Kannan M. Krishnan.
502 $a Thesis (Ph.D.) $c University of Washington $d 2017.
504 $a Includes bibliographical references
520 $a Fe3O4-magetite nanoparticles have received wide interest as prominent agents for various biomedical applications, ranging from target-specific cancer treatment, gene therapy, and Magnetic Particle Imaging (MPI). However, Fe3O4-magnetite nanoparticles, synthesized by chemical methods beyond a certain size, present challenges in controlling size distribution and shape. Similarly, Fe3O 4-magnetite nanoparticles fabricated by conventional top-down lithographic methods present difficulty of controlling defects and lead to agglomeration due to large size. In order to overcome the difficulties associated with the conventional chemical and top-down lithographic methods, it is critical to develop a fabrication method which produces homogeneous nanoparticles in large quantities with the control of size, defects, and structure.
520 $a Furthermore, the concept of cell death induced by mechanical perturbation has received wide attention as a way to maximize the cancer cell death with minimal side effects. Previous study has proposed the use of permalloy disk-shaped vortex state microparticles, in order to create cancer cell death by mechanical force. However, insufficient biocompatibility, inadequate mechanical force created by vortex switching, and inability to control the particle size have been critical issues to be further researched and proceeded for in vivo application.
520 $a Hence, we studied physical and magnetic properties of Fe3O 4 as a material in thin film form and proceeded to develop Fe3 O4 based synthetic antiferromagnetic (SAF) thin films. Then, we combined these favorable physical/magnetic properties with nanoimprint lithography to fabricate homogeneously patterned synthetic antiferromagnetic (SAF) nanoparticles (wafer area >1 x 1 cm2) with the control of size, shape and structure. Then we demonstrated the release of these particles in an aqueous environment. The fabrication process combines a tetrafluoroethylene (ETFE) "working stamp", a bi-layer resist lift-off, defect-free nanoimprint and sputtering in order to fabricate synthetic antiferromagnetic (SAF) nanoparticles. SAF nanoparticles are composed of alternating magnetic/non-magnetic multilayers to prevent any agglomeration in spite of the ferromagnetic nature of the particles. This heterostructure gives rise to nearly zero magnetic remanence and coercivity values and also prevents possible oxidation of Fe 3O4. The superparamagnet-like behavior (nearly zero remanence and coercivity) of SAF nanoparticles suggests that the SAF nanoparticles with favorable geometry fabricated by top-down methods have potential for biomedical application.
520 $a In order to prove the suitability of SAF nanoparticles for biomedical application, we initially controlled the movement of these SAF nanoparticles with A.C magnetic field, and mechanically rotated them in solution. After we have studied field frequency dependence on mechanical rotation, these SAF nanoparticles were implemented in in vitro environment to test the biocompatibility of these SAF nanoparticlesn, and also to confirm the effectiveness of mechanical force created by A.C magnetic field in order to kill cancer cells. This proof of concept successfully eradicated cancer cells with these SAF nanoparticles. We have demonstrated the effective cancer death after 16 minutes of exposure to mechanically rotating SAF nanoparticles under frequency of 1 Hz (>92% cell death). Furthermore, under the same frequency and exposure time, we have shown that up to 1:4 (nanoparticles:cell) concentration, the mechanical perturbation is effective to kill cancer cells (>80% cell death). However, we suggest to further study the biological mechanism of cancer cell death by mechanical perturbation to truly understand this phenomenon.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Materials science. $3 557839
655 7 $a Electronic books. $2 local $3 554714
690 $a 0794
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Washington. $b Materials Science and Engineering. $3 1182422
773 0 $t Dissertation Abstracts International $g 79-01B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10280500 $z click for full text (PQDT)