國立虎尾科技大學 |

Biological/Chemical Sensing System Based on Degradable Hydrogel with Fiber Optics or Microfluidics.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Biological/Chemical Sensing System Based on Degradable Hydrogel with Fiber Optics or Microfluidics./
作者:	Wu, Xiudong.
面頁冊數:	1 online resource (144 pages)
附註:	Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
Contained By:	Dissertation Abstracts International79-01B(E).
標題:	Electrical engineering. -
電子資源:	click for full text (PQDT)
ISBN:	9780355230529

Biological/Chemical Sensing System Based on Degradable Hydrogel with Fiber Optics or Microfluidics.
Wu, Xiudong.

Biological/Chemical Sensing System Based on Degradable Hydrogel with Fiber Optics or Microfluidics. - 1 online resource (144 pages)

Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

We developed a prototype of polyacrylamide (PAAm) -based sensor platform which can be used to detect chemical- and bio- agent with low-cost, easy-to-use, fast screening, and in-site detecting tool. By changing the cross-linker of the hydrogel, various agents can be detected. We firstly integrated the hydrogel into a microchannel, and developed a BoNT sensor based on the morphology change of this hydrogel. The hydrogel in the microchannel can be degraded in 22 h at 45 mug/mL of light chain (LC) of botulinum toxin type A (BoNT/A) and 90 h at the lowest concentration of 4.5 mug/mL of LC. To improve the sensitivity and testing time of the hydrogel-based bio-toxin sensors, we introduce an optical fiber Fabry Perot interferometer (FPI) to detect the changes in the optical properties induced by the reactions between the target agent and the hydrogel. Compared to our previous hydrogel-based sensor based on the microscopy observation, the sensitivity of the optic fiber FPI is improved by 2000 times, and testing time is shortened from tens of hours to a few hours. In order to further enhance the sensitivity and detection speed, we combined the fiber optics with microfluidics. The preliminary study of the combination showed that the LC of 4.5 mug/ml was detected in 24 hours, while the previous detection time was about 90 hours. Due to the combination, the detection speed was further increased by 4 times. Our approach opens up an avenue for highly-sensitive, high-speed in-field detection of bio-toxins in live samples.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355230529Subjects--Topical Terms:

596380
Electrical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Biological/Chemical Sensing System Based on Degradable Hydrogel with Fiber Optics or Microfluidics.
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500 $a Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
500 $a Adviser: Hongrui Jiang.
502 $a Thesis (Ph.D.) $c The University of Wisconsin - Madison $d 2017.
504 $a Includes bibliographical references
520 $a We developed a prototype of polyacrylamide (PAAm) -based sensor platform which can be used to detect chemical- and bio- agent with low-cost, easy-to-use, fast screening, and in-site detecting tool. By changing the cross-linker of the hydrogel, various agents can be detected. We firstly integrated the hydrogel into a microchannel, and developed a BoNT sensor based on the morphology change of this hydrogel. The hydrogel in the microchannel can be degraded in 22 h at 45 mug/mL of light chain (LC) of botulinum toxin type A (BoNT/A) and 90 h at the lowest concentration of 4.5 mug/mL of LC. To improve the sensitivity and testing time of the hydrogel-based bio-toxin sensors, we introduce an optical fiber Fabry Perot interferometer (FPI) to detect the changes in the optical properties induced by the reactions between the target agent and the hydrogel. Compared to our previous hydrogel-based sensor based on the microscopy observation, the sensitivity of the optic fiber FPI is improved by 2000 times, and testing time is shortened from tens of hours to a few hours. In order to further enhance the sensitivity and detection speed, we combined the fiber optics with microfluidics. The preliminary study of the combination showed that the LC of 4.5 mug/ml was detected in 24 hours, while the previous detection time was about 90 hours. Due to the combination, the detection speed was further increased by 4 times. Our approach opens up an avenue for highly-sensitive, high-speed in-field detection of bio-toxins in live samples.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
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710 2 $a The University of Wisconsin - Madison. $b Electrical Engineering. $3 1178889
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