國立虎尾科技大學 |

Designer gene circuits for basic science, engineering, and medicine.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Designer gene circuits for basic science, engineering, and medicine./
作者:	Prindle, Arthur.
面頁冊數:	1 online resource (115 pages)
附註:	Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
Contained By:	Dissertation Abstracts International75-08B(E).
標題:	Genetics. -
電子資源:	click for full text (PQDT)
ISBN:	9781303896996

Designer gene circuits for basic science, engineering, and medicine.
Prindle, Arthur.

Designer gene circuits for basic science, engineering, and medicine. - 1 online resource (115 pages)

Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

Gene regulatory networks lay at the foundation of biological function and are responsible for driving the diverse cellular decision making processes required to sustain life. Developing a comprehensive understanding of cellular function will require a quantitative description of the dynamics of these underlying interactions. The ability to design synthetic gene circuits offers the exciting prospect of prototyping new genetic subsystems inspired by the inherently complex networks of natural organisms. An increasingly vivid representation of the design principles that drive biological function is assembled through the systematic design and characterization of experimentally tractable synthetic modules of increasing complexity. The programming of living cells according to these principles will provide fundamental insights into the regulatory architecture, dynamics, and evolution of natural networks and open new avenues in biotechnology by revealing novel ways to program genetic modules.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781303896996Subjects--Topical Terms:

578972
Genetics.
Index Terms--Genre/Form:

554714
Electronic books.

Designer gene circuits for basic science, engineering, and medicine.
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100 1 $a Prindle, Arthur. $3 1184253
245 1 0 $a Designer gene circuits for basic science, engineering, and medicine.
264 0 $c 2014
300 $a 1 online resource (115 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
500 $a Adviser: Jeff Hasty.
502 $a Thesis (Ph.D.) $c University of California, San Diego $d 2014.
504 $a Includes bibliographical references
520 $a Gene regulatory networks lay at the foundation of biological function and are responsible for driving the diverse cellular decision making processes required to sustain life. Developing a comprehensive understanding of cellular function will require a quantitative description of the dynamics of these underlying interactions. The ability to design synthetic gene circuits offers the exciting prospect of prototyping new genetic subsystems inspired by the inherently complex networks of natural organisms. An increasingly vivid representation of the design principles that drive biological function is assembled through the systematic design and characterization of experimentally tractable synthetic modules of increasing complexity. The programming of living cells according to these principles will provide fundamental insights into the regulatory architecture, dynamics, and evolution of natural networks and open new avenues in biotechnology by revealing novel ways to program genetic modules.
520 $a In Chapter One, I give an introduction to the genetic circuits approach by relating a survey of recent research that has been influential for me. In Chapter Two, I discuss my work on integrated "bacto-electronic" sensors that communicate over supermicrobial spatial scales. In Chapter Three, I discuss engineered gene circuits in the clinically relevant microbe S. typhimurium . In Chapter Four, I discuss a rapid and tunable post-translational coupling method for genetic circuits. In Chapter Five, I discuss designer probiotics for non-invasive cancer diagnostics. The unifying goal of these efforts is a "bottom-up" approach to building gene circuits predicted to confer a particular behavior based on engineering principles.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Genetics. $3 578972
650 4 $a Bioinformatics. $3 583857
655 7 $a Electronic books. $2 local $3 554714
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690 $a 0715
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, San Diego. $b Bioengineering. $3 1180910
773 0 $t Dissertation Abstracts International $g 75-08B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3620022 $z click for full text (PQDT)