語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Role of the Cyclic Guanosine Monopho...
~
Texas A&M University - Corpus Christi.
Role of the Cyclic Guanosine Monophosphate Pathway on the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Sea Hare, Aplysia Californica.
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
Role of the Cyclic Guanosine Monophosphate Pathway on the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Sea Hare, Aplysia Californica./
作者:
Chatterji, Ruma.
面頁冊數:
1 online resource (69 pages)
附註:
Source: Masters Abstracts International, Volume: 56-06.
標題:
Neurosciences. -
電子資源:
click for full text (PQDT)
ISBN:
9780355138931
Role of the Cyclic Guanosine Monophosphate Pathway on the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Sea Hare, Aplysia Californica.
Chatterji, Ruma.
Role of the Cyclic Guanosine Monophosphate Pathway on the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Sea Hare, Aplysia Californica.
- 1 online resource (69 pages)
Source: Masters Abstracts International, Volume: 56-06.
Thesis (M.Sc.)--Texas A&M University - Corpus Christi, 2017.
Includes bibliographical references
The ability to make decisions when in a state of trepidation is a universal and crucial component of organism survival. Studying behavior and the underlying cellular mechanisms in parallel is needed, but rarely achieved due to the complexity of the nervous system and the difficulty to link behaviors to cellular substrates. Therefore, the goal of this project was to examine both behavioral and neuronal plasticity using the marine mollusk Aplysia, an organism with quantifiable behaviors controlled by well-characterized neural circuitry. In Aplysia, exposure to aversive stimuli causes a learned suppression of a non-defensive behavior (i.e., feeding) and a learned enhancement of a defensive response (a form of learning called sensitization) of the tail-siphon withdrawal reflex (TSWR). Correspondingly, at the cellular level, exposure to the aversive stimuli causes a decrease in excitability of B51, a decision-making neuron controlling feeding, and an increase in excitability of tail sensory neurons (TSNs) responsible for the TSWR. The Cyclic Guanosine Monophosphate (cGMP) pathway dependent on protein kinase G (PKG) is involved in learning-dependent behavioral and neuronal plasticity associated with non-defensive and defensive responses in Aplysia. The aims of this thesis were: 1) to investigate the role of PKG in feeding suppression and sensitization in vivo and 2) to examine the role of PKG in neural correlates underlying feeding suppression via B51 excitability and sensitization via TSN excitability in vitro. Selective inhibitor KT5823 was used to block PKG activity. Findings from in vivo experiments indicate that KT5823 did not prevent either feeding suppression or sensitization induced by aversive stimuli. Concurrently, in vitro results determined that KT5823 did not prevent the learning-induced decreased excitability of B51 and also did not prevent the learning-induced increase in TSN excitability. These results suggest that PKG may not contribute to the behavioral or neuronal plasticity induced by aversive stimuli in Aplysia. Future directions include investigation of other potential downstream targets such as cyclic-nucleotide gated ion channels and phosphodiesterases.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018
Mode of access: World Wide Web
ISBN: 9780355138931Subjects--Topical Terms:
593561
Neurosciences.
Index Terms--Genre/Form:
554714
Electronic books.
Role of the Cyclic Guanosine Monophosphate Pathway on the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Sea Hare, Aplysia Californica.
LDR
:03453ntm a2200325K 4500
001
913304
005
20180618102610.5
006
m o u
007
cr mn||||a|a||
008
190606s2017 xx obm 000 0 eng d
020
$a
9780355138931
035
$a
(MiAaPQ)AAI10607635
035
$a
(MiAaPQ)tamucc:10281
035
$a
AAI10607635
040
$a
MiAaPQ
$b
eng
$c
MiAaPQ
100
1
$a
Chatterji, Ruma.
$3
1186083
245
1 0
$a
Role of the Cyclic Guanosine Monophosphate Pathway on the Behavioral and Neuronal Plasticity Induced by Aversive Stimuli in the Sea Hare, Aplysia Californica.
264
0
$c
2017
300
$a
1 online resource (69 pages)
336
$a
text
$b
txt
$2
rdacontent
337
$a
computer
$b
c
$2
rdamedia
338
$a
online resource
$b
cr
$2
rdacarrier
500
$a
Source: Masters Abstracts International, Volume: 56-06.
500
$a
Adviser: Riccardo Mozzachiodi.
502
$a
Thesis (M.Sc.)--Texas A&M University - Corpus Christi, 2017.
504
$a
Includes bibliographical references
520
$a
The ability to make decisions when in a state of trepidation is a universal and crucial component of organism survival. Studying behavior and the underlying cellular mechanisms in parallel is needed, but rarely achieved due to the complexity of the nervous system and the difficulty to link behaviors to cellular substrates. Therefore, the goal of this project was to examine both behavioral and neuronal plasticity using the marine mollusk Aplysia, an organism with quantifiable behaviors controlled by well-characterized neural circuitry. In Aplysia, exposure to aversive stimuli causes a learned suppression of a non-defensive behavior (i.e., feeding) and a learned enhancement of a defensive response (a form of learning called sensitization) of the tail-siphon withdrawal reflex (TSWR). Correspondingly, at the cellular level, exposure to the aversive stimuli causes a decrease in excitability of B51, a decision-making neuron controlling feeding, and an increase in excitability of tail sensory neurons (TSNs) responsible for the TSWR. The Cyclic Guanosine Monophosphate (cGMP) pathway dependent on protein kinase G (PKG) is involved in learning-dependent behavioral and neuronal plasticity associated with non-defensive and defensive responses in Aplysia. The aims of this thesis were: 1) to investigate the role of PKG in feeding suppression and sensitization in vivo and 2) to examine the role of PKG in neural correlates underlying feeding suppression via B51 excitability and sensitization via TSN excitability in vitro. Selective inhibitor KT5823 was used to block PKG activity. Findings from in vivo experiments indicate that KT5823 did not prevent either feeding suppression or sensitization induced by aversive stimuli. Concurrently, in vitro results determined that KT5823 did not prevent the learning-induced decreased excitability of B51 and also did not prevent the learning-induced increase in TSN excitability. These results suggest that PKG may not contribute to the behavioral or neuronal plasticity induced by aversive stimuli in Aplysia. Future directions include investigation of other potential downstream targets such as cyclic-nucleotide gated ion channels and phosphodiesterases.
533
$a
Electronic reproduction.
$b
Ann Arbor, Mich. :
$c
ProQuest,
$d
2018
538
$a
Mode of access: World Wide Web
650
4
$a
Neurosciences.
$3
593561
650
4
$a
Biology.
$3
599573
655
7
$a
Electronic books.
$2
local
$3
554714
690
$a
0317
690
$a
0306
710
2
$a
ProQuest Information and Learning Co.
$3
1178819
710
2
$a
Texas A&M University - Corpus Christi.
$b
Biology.
$3
1186084
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10607635
$z
click for full text (PQDT)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入