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Characterizing the Role of ice1 in M...

University of Toronto (Canada).

Characterizing the Role of ice1 in Maintaining Zebrafish Neural Stem Cells.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Characterizing the Role of ice1 in Maintaining Zebrafish Neural Stem Cells./
作者:	D'Amata, Cassandra Marie.
面頁冊數:	1 online resource (95 pages)
附註:	Source: Masters Abstracts International, Volume: 57-02.
標題:	Cellular biology. -
電子資源:	click for full text (PQDT)
ISBN:	9780355449556

Characterizing the Role of ice1 in Maintaining Zebrafish Neural Stem Cells.
D'Amata, Cassandra Marie.

Characterizing the Role of ice1 in Maintaining Zebrafish Neural Stem Cells. - 1 online resource (95 pages)

Source: Masters Abstracts International, Volume: 57-02.

Thesis (M.Sc.)--University of Toronto (Canada), 2017.

Includes bibliographical references

Maintenance of neural stem cell (NSC) niches is required for the continued growth of the zebrafish retina and forebrain after embryogenesis. The zebrafish mutant kess564, which maps to the ice1 locus, exhibits reduced NSC niches. RNA polymerase II-dependent snRNA transcription requires the little elongation complex (LEC) for which ICE1 is an essential scaffolding component. Mutant NSCs which are normally active no longer express markers of cycling cells and become apoptotic. Furthermore, quiescent NSCs of the mutant retina are unable to dedifferentiate in response to UV lesion. Whole-transcriptome analysis of ice1 mutant larvae show a decrease in CNS and cell cycle levels, and an increase in splicing genes indicative of a possible compensatory mechanism. snRNA transcript levels appear to be unaffected in a subset of NSCs but reduced in differentiated neurons. This work demonstrates that ice1 is essential for NSC maintenance in an in vivo loss of function model.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355449556Subjects--Topical Terms:

1148666
Cellular biology.
Index Terms--Genre/Form:

554714
Electronic books.

Characterizing the Role of ice1 in Maintaining Zebrafish Neural Stem Cells.
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245 1 0 $a Characterizing the Role of ice1 in Maintaining Zebrafish Neural Stem Cells.
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500 $a Source: Masters Abstracts International, Volume: 57-02.
500 $a Adviser: Vincent Tropepe.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2017.
504 $a Includes bibliographical references
520 $a Maintenance of neural stem cell (NSC) niches is required for the continued growth of the zebrafish retina and forebrain after embryogenesis. The zebrafish mutant kess564, which maps to the ice1 locus, exhibits reduced NSC niches. RNA polymerase II-dependent snRNA transcription requires the little elongation complex (LEC) for which ICE1 is an essential scaffolding component. Mutant NSCs which are normally active no longer express markers of cycling cells and become apoptotic. Furthermore, quiescent NSCs of the mutant retina are unable to dedifferentiate in response to UV lesion. Whole-transcriptome analysis of ice1 mutant larvae show a decrease in CNS and cell cycle levels, and an increase in splicing genes indicative of a possible compensatory mechanism. snRNA transcript levels appear to be unaffected in a subset of NSCs but reduced in differentiated neurons. This work demonstrates that ice1 is essential for NSC maintenance in an in vivo loss of function model.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Cellular biology. $3 1148666
650 4 $a Developmental biology. $3 669036
650 4 $a Molecular biology. $3 583443
655 7 $a Electronic books. $2 local $3 554714
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710 2 $a University of Toronto (Canada). $b Cell and Systems Biology. $3 1186171
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