國立虎尾科技大學 |

Intergenerational Effects of Embryonic Cocaine Exposure in Zebrafish.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Intergenerational Effects of Embryonic Cocaine Exposure in Zebrafish./
Author:	Boyle, Cody.
Description:	1 online resource (138 pages)
Notes:	Source: Masters Abstracts International, Volume: 57-02.
Subject:	Biology. -
Online resource:	click for full text (PQDT)
ISBN:	9780355554618

Intergenerational Effects of Embryonic Cocaine Exposure in Zebrafish.
Boyle, Cody.

Intergenerational Effects of Embryonic Cocaine Exposure in Zebrafish. - 1 online resource (138 pages)

Source: Masters Abstracts International, Volume: 57-02.

Thesis (M.S.)--The University of North Dakota, 2017.

Includes bibliographical references

Cocaine addiction has both genetic and environmentally driven components. Relatively recently several groups have suggested that epigenetic regulation of gene expression might be the mechanism linking environmental influence and inheritance in drug addiction. We have shown previously that embryonic cocaine exposure increases physiological and behavioral sensitivity to the drug in longitudinal adults. In this study, we provide evidence that the effects of embryonic pre-exposure to cocaine are intergenerational in zebrafish. In addition, we show how gene expression in the zebrafish telencephalon, which includes the teleost equivalent of the nucleus accumbens, changes during acute cocaine treatment during behavioral testing. These experiments outline gene expression pathways not extensively studied in the context of cocaine response. We show how embryonic exposure to cocaine affects these gene expression pathways when the longitudinal animals are acutely exposed. Finally, we show how chronic embryonic exposure affects these same pathways in 5-day old embryos.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355554618Subjects--Topical Terms:

599573
Biology.
Index Terms--Genre/Form:

554714
Electronic books.

Intergenerational Effects of Embryonic Cocaine Exposure in Zebrafish.
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500 $a Source: Masters Abstracts International, Volume: 57-02.
500 $a Adviser: Tristan Darland.
502 $a Thesis (M.S.)--The University of North Dakota, 2017.
504 $a Includes bibliographical references
520 $a Cocaine addiction has both genetic and environmentally driven components. Relatively recently several groups have suggested that epigenetic regulation of gene expression might be the mechanism linking environmental influence and inheritance in drug addiction. We have shown previously that embryonic cocaine exposure increases physiological and behavioral sensitivity to the drug in longitudinal adults. In this study, we provide evidence that the effects of embryonic pre-exposure to cocaine are intergenerational in zebrafish. In addition, we show how gene expression in the zebrafish telencephalon, which includes the teleost equivalent of the nucleus accumbens, changes during acute cocaine treatment during behavioral testing. These experiments outline gene expression pathways not extensively studied in the context of cocaine response. We show how embryonic exposure to cocaine affects these gene expression pathways when the longitudinal animals are acutely exposed. Finally, we show how chronic embryonic exposure affects these same pathways in 5-day old embryos.
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538 $a Mode of access: World Wide Web
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650 4 $a Developmental biology. $3 669036
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