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Characterization of hippocampal subregional cross-frequency associations, and the effect of Deep Brain Stimulation on memory performance in Humans.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Characterization of hippocampal subregional cross-frequency associations, and the effect of Deep Brain Stimulation on memory performance in Humans./
Author:	Tchemodanov, Natalia.
Description:	1 online resource (99 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9781369293562

Characterization of hippocampal subregional cross-frequency associations, and the effect of Deep Brain Stimulation on memory performance in Humans.
Tchemodanov, Natalia.

Characterization of hippocampal subregional cross-frequency associations, and the effect of Deep Brain Stimulation on memory performance in Humans. - 1 online resource (99 pages)

Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2016.

Includes bibliographical references

Deep brain stimulation (DBS) of the Medial Temporal Lobe (MTL) in humans has offered promise for improving hippocampal-dependent learning and memory, yet little is known about how it modulates the electrophysiological mechanisms associated with hippocampal communication. Here, we explore the role of theta-gamma coupling, a putative entorhinal- hippocampal organizing mechanism, in successful memory formation, while human subjects implanted with intracranial electrodes engage in hippocampal-dependent memory tasks. Our results suggest that entorhinal area DBS, previously shown to be associated with memory enhancement, also results in substantial coupling of theta and gamma oscillations within the hippocampus, suggesting a possible mechanism for stimulation related memory enhancement. Further, we address hippocampal cross-frequency dynamics during encoding and retrieval at the level of hippocampal subfields, showing that CA1 theta high-gamma coupling increases preferentially during encoding of subsequently recollected objects, while both CA1 and CA2- 3-DG exhibit memory specific cross-frequency coupling changes during retrieval. Finally, we perform a multi-task analysis to assess how generalizable is the effect of DBS across multiple entorhinal stimulation targets, memory modalities, and stimulation protocols; our results show that stimulation of entorhinal white matter enhances declarative memory encoding.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369293562Subjects--Topical Terms:

593561
Neurosciences.
Index Terms--Genre/Form:

554714
Electronic books.

Characterization of hippocampal subregional cross-frequency associations, and the effect of Deep Brain Stimulation on memory performance in Humans.
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100 1 $a Tchemodanov, Natalia. $3 1186587
245 1 0 $a Characterization of hippocampal subregional cross-frequency associations, and the effect of Deep Brain Stimulation on memory performance in Humans.
264 0 $c 2016
300 $a 1 online resource (99 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.
500 $a Advisers: Itzhak Fried; Dario Ringach.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2016.
504 $a Includes bibliographical references
520 $a Deep brain stimulation (DBS) of the Medial Temporal Lobe (MTL) in humans has offered promise for improving hippocampal-dependent learning and memory, yet little is known about how it modulates the electrophysiological mechanisms associated with hippocampal communication. Here, we explore the role of theta-gamma coupling, a putative entorhinal- hippocampal organizing mechanism, in successful memory formation, while human subjects implanted with intracranial electrodes engage in hippocampal-dependent memory tasks. Our results suggest that entorhinal area DBS, previously shown to be associated with memory enhancement, also results in substantial coupling of theta and gamma oscillations within the hippocampus, suggesting a possible mechanism for stimulation related memory enhancement. Further, we address hippocampal cross-frequency dynamics during encoding and retrieval at the level of hippocampal subfields, showing that CA1 theta high-gamma coupling increases preferentially during encoding of subsequently recollected objects, while both CA1 and CA2- 3-DG exhibit memory specific cross-frequency coupling changes during retrieval. Finally, we perform a multi-task analysis to assess how generalizable is the effect of DBS across multiple entorhinal stimulation targets, memory modalities, and stimulation protocols; our results show that stimulation of entorhinal white matter enhances declarative memory encoding.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 593561
650 4 $a Biomedical engineering. $3 588770
655 7 $a Electronic books. $2 local $3 554714
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690 $a 0541
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710 2 $a University of California, Los Angeles. $b Biomedical Engineering 0289. $3 1186588
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10179989 $z click for full text (PQDT)