國立虎尾科技大學 |

Cognitive Control of Emotional Information in Schizophrenia : = Understanding the Mechanisms of Social Functioning Impairments.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Cognitive Control of Emotional Information in Schizophrenia :/
其他題名:	Understanding the Mechanisms of Social Functioning Impairments.
作者:	Tully, Laura Magdalen.
面頁冊數:	1 online resource (132 pages)
附註:	Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
標題:	Clinical psychology. -
電子資源:	click for full text (PQDT)
ISBN:	9781303503276

Cognitive Control of Emotional Information in Schizophrenia : = Understanding the Mechanisms of Social Functioning Impairments.
Tully, Laura Magdalen.

Cognitive Control of Emotional Information in Schizophrenia :Understanding the Mechanisms of Social Functioning Impairments. - 1 online resource (132 pages)

Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.

Thesis (Ph.D.)--Harvard University, 2013.

Includes bibliographical references

Social functioning impairments are a core, debilitating, and treatment refractory feature of schizophrenia. The mechanisms contributing to these impairments are unknown. Cognitive control mechanisms, mediated by the lateral prefrontal cortex (LPFC), are known to influence response to interpersonal stressors in healthy individuals, thus impairments in these processes may contribute to social deficits. Deficits in cognitive control and lateral prefrontal abnormalities are well-documented in schizophrenia, but the relationship between these deficits and social interactions has received limited attention in the literature. The current dissertation presents a systematic examination of the contribution of the behavioral and neural mechanisms of cognitive control to social functioning impairments in schizophrenia. Three papers are presented.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781303503276Subjects--Topical Terms:

649607
Clinical psychology.
Index Terms--Genre/Form:

554714
Electronic books.

Cognitive Control of Emotional Information in Schizophrenia : = Understanding the Mechanisms of Social Functioning Impairments.
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245 1 0 $a Cognitive Control of Emotional Information in Schizophrenia : $b Understanding the Mechanisms of Social Functioning Impairments.
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300 $a 1 online resource (132 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
500 $a Adviser: Christine I. Hooker.
502 $a Thesis (Ph.D.)--Harvard University, 2013.
504 $a Includes bibliographical references
520 $a Social functioning impairments are a core, debilitating, and treatment refractory feature of schizophrenia. The mechanisms contributing to these impairments are unknown. Cognitive control mechanisms, mediated by the lateral prefrontal cortex (LPFC), are known to influence response to interpersonal stressors in healthy individuals, thus impairments in these processes may contribute to social deficits. Deficits in cognitive control and lateral prefrontal abnormalities are well-documented in schizophrenia, but the relationship between these deficits and social interactions has received limited attention in the literature. The current dissertation presents a systematic examination of the contribution of the behavioral and neural mechanisms of cognitive control to social functioning impairments in schizophrenia. Three papers are presented.
520 $a Paper #1 demonstrates that individual differences in social anhedonia---an established personality risk factor for schizophrenia and a core negative symptom of the disease---relate to social impairments and that this relationship is partially mediated by self-reported cognitive control. Using surface based morphometry methods, paper #2 establishes a relationship between decreased cortical thickness in the LPFC (superior frontal gyrus) and decreased role functioning across a sample of schizophrenia and healthy participants; moreover, cognitive control fully mediated this relationship. Paper #3 combined functional MRI and experience sampling methods to established a relationship between lateral prefrontal dysfunction during cognitive control, specifically of emotional information, and daily social experiences in schizophrenia. Schizophrenia participants showed reduced LPFC activation during cognitive control of negative emotional information. Moreover, the extent of LPFC activation during cognitive control of negative emotional information predicted symptom exacerbation and daily social experiences.
520 $a Taken together, the three papers of this dissertation clearly establish impaired cognitive control as one of the mechanisms underlying functional impairment in schizophrenia, demonstrating a direct link between a putative biomarker for schizophrenia (LPFC dysfunction), and one of the core behavioral characteristics of the illness---social impairments. This dissertation addresses important gaps in our understanding of the relationship between the neurofunctional and neuroanatomical mechanisms of cognitive control, and real-world functioning. These findings suggest that cognitive control, specifically of emotional information, could be a potential target for intervention to ameliorate social deficits in schizophrenia.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
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710 2 $a Harvard University. $b Psychology. $3 1186626
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