國立虎尾科技大學 |

Neural signatures of human episodic memory consolidation during awake rest.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Neural signatures of human episodic memory consolidation during awake rest./
Author:	Tambini, Arielle.
Description:	1 online resource (273 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 75-03(E), Section: B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9781303559730

Neural signatures of human episodic memory consolidation during awake rest.
Tambini, Arielle.

Neural signatures of human episodic memory consolidation during awake rest. - 1 online resource (273 pages)

Source: Dissertation Abstracts International, Volume: 75-03(E), Section: B.

Thesis (Ph.D.)--New York University, 2013.

Includes bibliographical references

Our remarkable ability to form, retain, and retrieve memories of single episodic experiences is an impressive biological feat. Evidence from multiple species has indicated that the hippocampus plays a critical role in the initial formation of novel episodic memories. Over time, the strengthening or consolidation of memories is thought to be mediated by the post-encoding reactivation of hippocampal activity patterns representing recent experiences, in conjunction with hippocampal-cortical interactions. Prior work in rodents has demonstrated that such post-encoding processes occur during off-line sleep and awake periods, and has shown that these processes are related to memory for recent experiences. This thesis explores whether potential evidence can be found for similar post-encoding processes during awake rest periods in humans, by measuring connectivity with functional magnetic resonance imaging (fMRI). In Chapter 1, we found that patterns of connectivity within the hippocampus that were characteristic of two distinct episodic encoding experiences showed evidence of persistence during post- encoding rest periods, and that this persistence was related to memory for stimuli seen during these distinct encoding experiences. In Chapter 2, we demonstrated that overall levels of hippocampal-cortical and cortico-cortical resting connectivity could be enhanced after episodic encoding experiences, depending on overall levels of memory for recent experiences. In particular, changes in post-encoding hippocampal-cortical connectivity were related to individual subjects' associative memory for recently viewed stimulus pairs. Lastly, in Chapter 3, we asked whether the presence of emotion during encoding, a factor known to enhance hippocampal-dependent memory consolidation, modulates overall levels of connectivity during post-encoding rest. We did not find evidence for such a modulation of overall post-encoding connectivity levels based on emotion, but instead found that the content of recent experience (exposure to emotional vs. neutral stimuli) modulates the brain structures that are related to memory for these experiences during post- encoding rest. Together, this work provides novel evidence that activity during post-encoding awake rest in humans may be relevant for memory consolidation, and opens a new line of work examining post-encoding connectivity as a window into consolidation processes occurring in humans.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781303559730Subjects--Topical Terms:

593561
Neurosciences.
Index Terms--Genre/Form:

554714
Electronic books.

Neural signatures of human episodic memory consolidation during awake rest.
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520 $a Our remarkable ability to form, retain, and retrieve memories of single episodic experiences is an impressive biological feat. Evidence from multiple species has indicated that the hippocampus plays a critical role in the initial formation of novel episodic memories. Over time, the strengthening or consolidation of memories is thought to be mediated by the post-encoding reactivation of hippocampal activity patterns representing recent experiences, in conjunction with hippocampal-cortical interactions. Prior work in rodents has demonstrated that such post-encoding processes occur during off-line sleep and awake periods, and has shown that these processes are related to memory for recent experiences. This thesis explores whether potential evidence can be found for similar post-encoding processes during awake rest periods in humans, by measuring connectivity with functional magnetic resonance imaging (fMRI). In Chapter 1, we found that patterns of connectivity within the hippocampus that were characteristic of two distinct episodic encoding experiences showed evidence of persistence during post- encoding rest periods, and that this persistence was related to memory for stimuli seen during these distinct encoding experiences. In Chapter 2, we demonstrated that overall levels of hippocampal-cortical and cortico-cortical resting connectivity could be enhanced after episodic encoding experiences, depending on overall levels of memory for recent experiences. In particular, changes in post-encoding hippocampal-cortical connectivity were related to individual subjects' associative memory for recently viewed stimulus pairs. Lastly, in Chapter 3, we asked whether the presence of emotion during encoding, a factor known to enhance hippocampal-dependent memory consolidation, modulates overall levels of connectivity during post-encoding rest. We did not find evidence for such a modulation of overall post-encoding connectivity levels based on emotion, but instead found that the content of recent experience (exposure to emotional vs. neutral stimuli) modulates the brain structures that are related to memory for these experiences during post- encoding rest. Together, this work provides novel evidence that activity during post-encoding awake rest in humans may be relevant for memory consolidation, and opens a new line of work examining post-encoding connectivity as a window into consolidation processes occurring in humans.
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