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Path Integral Techniques for Estimat...
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ProQuest Information and Learning Co.
Path Integral Techniques for Estimating Neural Network Connectivity.
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
Path Integral Techniques for Estimating Neural Network Connectivity./
作者:
Knowlton, Christopher J.
面頁冊數:
1 online resource (141 pages)
附註:
Source: Dissertation Abstracts International, Volume: 76-05(E), Section: B.
標題:
Biophysics. -
電子資源:
click for full text (PQDT)
ISBN:
9781321401745
Path Integral Techniques for Estimating Neural Network Connectivity.
Knowlton, Christopher J.
Path Integral Techniques for Estimating Neural Network Connectivity.
- 1 online resource (141 pages)
Source: Dissertation Abstracts International, Volume: 76-05(E), Section: B.
Thesis (Ph.D.)--University of California, San Diego, 2014.
Includes bibliographical references
Characterizing the behavior of networks of neurons requires accounting for the differing levels of measurements at different scales. At the single neuron level, intracellular recordings allow for highly accurate membrane potential measurements in response to an designed applied current. Because the probes used for the single neuron experiments are large compared to the cells themselves, these voltage measurements cannot be assumed to be available for any more than a few cells at a time. Instead of voltage measurements of the potential across the cell membrane, extracellular voltage measurements combined with spike sorting algorithms allow for measurements of spike times on orders of magnitude more neurons. This spike timing information provides much less information per neuron, requiring the development of new methods to estimate the states and connectivity of a network of neurons.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018
Mode of access: World Wide Web
ISBN: 9781321401745Subjects--Topical Terms:
581576
Biophysics.
Index Terms--Genre/Form:
554714
Electronic books.
Path Integral Techniques for Estimating Neural Network Connectivity.
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Characterizing the behavior of networks of neurons requires accounting for the differing levels of measurements at different scales. At the single neuron level, intracellular recordings allow for highly accurate membrane potential measurements in response to an designed applied current. Because the probes used for the single neuron experiments are large compared to the cells themselves, these voltage measurements cannot be assumed to be available for any more than a few cells at a time. Instead of voltage measurements of the potential across the cell membrane, extracellular voltage measurements combined with spike sorting algorithms allow for measurements of spike times on orders of magnitude more neurons. This spike timing information provides much less information per neuron, requiring the development of new methods to estimate the states and connectivity of a network of neurons.
520
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Previous work{biocyb1,biocyb2,cdm1} has demonstrated the ability of a path integral formulation to characterize the behavior of individual neurons given time series voltage data. We expand on this to potential future experiments to characterize the behavior of synaptic connections, and other external currents acting on neurons and two possible means for determining the connectivity of a network of neurons given spike timing information.
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