語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Genetic contributions to the evoluti...
~
ProQuest Information and Learning Co.
Genetic contributions to the evolution of human brain traits.
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
Genetic contributions to the evolution of human brain traits./
作者:
Boyd, Jonathan Lomax.
面頁冊數:
1 online resource (124 pages)
附註:
Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
標題:
Genetics. -
電子資源:
click for full text (PQDT)
ISBN:
9781321415322
Genetic contributions to the evolution of human brain traits.
Boyd, Jonathan Lomax.
Genetic contributions to the evolution of human brain traits.
- 1 online resource (124 pages)
Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
Thesis (Ph.D.)--Duke University, 2014.
Includes bibliographical references
The neocortex expanded spectacularly during human origins. That expansion is thought to form the foundation for our cognitive faculties underlying abstract reasoning and socialization. The human neocortex differs from that of other great apes in several notable regards including altered cell cycle, prolonged corticogenesis, and massively increased size. However, despite decades of effort, little progress has been made in uncovering the genetic contributions that underlie these differences that distinguish our species from closely related primate, such as chimpanzees. A subset of highly conserved non-coding regions that show rapid sequence changes along the human lineage are candidate loci for the development and evolution of uniquely human traits. Several studies have identified human-accelerated enhancers, but none have linked an expression difference to a organismal traits, such as brain sizes. Here we report the discovery of a human-accelerated regulatory enhancer (HARE5) near the Wnt receptor FRIZZLED-8 (FZD8). Using a variety of approaches, we demonstrate dramatic differences in human and chimpanzee HARE5 activity, with human HARE5 driving significantly strong expression. We show that HARE5 likely regulates FZD8 and that expression differences influence cell cycle kinetics, cortical layers, and brain size. At present, this would provide the first evidence of a human-chimpanzee genetic difference influencing the evolution of brain size.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018
Mode of access: World Wide Web
ISBN: 9781321415322Subjects--Topical Terms:
578972
Genetics.
Index Terms--Genre/Form:
554714
Electronic books.
Genetic contributions to the evolution of human brain traits.
LDR
:02637ntm a2200337K 4500
001
913758
005
20180622095237.5
006
m o u
007
cr mn||||a|a||
008
190606s2014 xx obm 000 0 eng d
020
$a
9781321415322
035
$a
(MiAaPQ)AAI3667365
035
$a
(MiAaPQ)duke:12685
035
$a
AAI3667365
040
$a
MiAaPQ
$b
eng
$c
MiAaPQ
100
1
$a
Boyd, Jonathan Lomax.
$3
1186724
245
1 0
$a
Genetic contributions to the evolution of human brain traits.
264
0
$c
2014
300
$a
1 online resource (124 pages)
336
$a
text
$b
txt
$2
rdacontent
337
$a
computer
$b
c
$2
rdamedia
338
$a
online resource
$b
cr
$2
rdacarrier
500
$a
Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
500
$a
Advisers: Gregory A. Wray; Debra L. Silver.
502
$a
Thesis (Ph.D.)--Duke University, 2014.
504
$a
Includes bibliographical references
520
$a
The neocortex expanded spectacularly during human origins. That expansion is thought to form the foundation for our cognitive faculties underlying abstract reasoning and socialization. The human neocortex differs from that of other great apes in several notable regards including altered cell cycle, prolonged corticogenesis, and massively increased size. However, despite decades of effort, little progress has been made in uncovering the genetic contributions that underlie these differences that distinguish our species from closely related primate, such as chimpanzees. A subset of highly conserved non-coding regions that show rapid sequence changes along the human lineage are candidate loci for the development and evolution of uniquely human traits. Several studies have identified human-accelerated enhancers, but none have linked an expression difference to a organismal traits, such as brain sizes. Here we report the discovery of a human-accelerated regulatory enhancer (HARE5) near the Wnt receptor FRIZZLED-8 (FZD8). Using a variety of approaches, we demonstrate dramatic differences in human and chimpanzee HARE5 activity, with human HARE5 driving significantly strong expression. We show that HARE5 likely regulates FZD8 and that expression differences influence cell cycle kinetics, cortical layers, and brain size. At present, this would provide the first evidence of a human-chimpanzee genetic difference influencing the evolution of brain size.
533
$a
Electronic reproduction.
$b
Ann Arbor, Mich. :
$c
ProQuest,
$d
2018
538
$a
Mode of access: World Wide Web
650
4
$a
Genetics.
$3
578972
650
4
$a
Evolution & development.
$3
1178838
650
4
$a
Neurosciences.
$3
593561
655
7
$a
Electronic books.
$2
local
$3
554714
690
$a
0369
690
$a
0412
690
$a
0317
710
2
$a
ProQuest Information and Learning Co.
$3
1178819
710
2
$a
Duke University.
$b
Genetics and Genomics.
$3
1186725
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3667365
$z
click for full text (PQDT)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入