國立虎尾科技大學 |

TiO2 Nanotubes on Titanium for Early Stage Osseointegration : = Understanding the Mechanical Stability, Bone Bonding and Infection Control Ability.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	TiO2 Nanotubes on Titanium for Early Stage Osseointegration :/
其他題名:	Understanding the Mechanical Stability, Bone Bonding and Infection Control Ability.
作者:	Shivaram, Anish.
面頁冊數:	1 online resource (230 pages)
附註:	Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.
標題:	Mechanical engineering. -
電子資源:	click for full text (PQDT)
ISBN:	9780355094312

TiO2 Nanotubes on Titanium for Early Stage Osseointegration : = Understanding the Mechanical Stability, Bone Bonding and Infection Control Ability.
Shivaram, Anish.

TiO2 Nanotubes on Titanium for Early Stage Osseointegration :Understanding the Mechanical Stability, Bone Bonding and Infection Control Ability. - 1 online resource (230 pages)

Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.

Thesis (Ph.D.)--Washington State University, 2017.

Includes bibliographical references

Titanium based alloys, despite having excellent material properties, fail in large numbers within the first 15 years when used for orthopaedic and load-bearing applications. Two main reasons for implant failure is (a) poor interfacial bonding between the implant and surrounding bone-tissue area which results in the aseptic loosening of the implants and (b) infection at the implantation or surgery site. These two main reasons for implant failure has been addressed throughout this research by proposing possible solutions to prevent it and help improve the implant life in vivo.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355094312Subjects--Topical Terms:

557493
Mechanical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

TiO2 Nanotubes on Titanium for Early Stage Osseointegration : = Understanding the Mechanical Stability, Bone Bonding and Infection Control Ability.
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500 $a Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.
500 $a Adviser: Amit Bandyopadhyay.
502 $a Thesis (Ph.D.)--Washington State University, 2017.
504 $a Includes bibliographical references
520 $a Titanium based alloys, despite having excellent material properties, fail in large numbers within the first 15 years when used for orthopaedic and load-bearing applications. Two main reasons for implant failure is (a) poor interfacial bonding between the implant and surrounding bone-tissue area which results in the aseptic loosening of the implants and (b) infection at the implantation or surgery site. These two main reasons for implant failure has been addressed throughout this research by proposing possible solutions to prevent it and help improve the implant life in vivo.
520 $a TiO2 nanotubes fabricated via electrochemical anodization technique on titanium surface is used throughout the research to address the implant failure issue and help improve the early stage osseointegrative properties in the form of four main research objectives. The first objective was addresses the mechanical stability of TiO2 nanotubes with and without silver coatings by testing it in an ex vivo implantation technique using an equine cadaver bone. The second objective helps understand the early stage osseointegrative properties of titanium implants with and without surface modification using a rat distal femur model. The third objective addresses the issue of infection using silver coatings on surface modified implants from a long-term point of view and helps us offer a long-term solution to control infection in vivo along with improving the bone bonding ability at the bone-implant interface. The last objective mainly focusses on further enhancing the surface properties of TiO2 nanotubes using two different approaches. First, using strontium, magnesium and zinc doped TiO2 nanotubes to further improve the cell-material interactions and second to study the effects of surface charge on TiO2 nanotubes for early stage osseointegration.
520 $a The results show mechanically stable TiO2 nanotubes up to 1microm length used on titanium surface were successful in improving the early stage osseointegrative properties. The use of silver coatings can provide a solution for infection control in vivo. The use of dopants and surface charge further helped enhancing the surface properties of TiO 2 nanotubes which would further enhance the early stage osseointegrative properties.
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