國立虎尾科技大學 |

Stereoselective Synthesis of Butenolides and its Applications in Total Synthesis of Sessilifoliamides and Development of New Chemical Tools for Hydrogel Based Biomaterials.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Stereoselective Synthesis of Butenolides and its Applications in Total Synthesis of Sessilifoliamides and Development of New Chemical Tools for Hydrogel Based Biomaterials./
作者:	Li, Yi.
面頁冊數:	1 online resource (264 pages)
附註:	Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.
標題:	Organic chemistry. -
電子資源:	click for full text (PQDT)
ISBN:	9780355260366

Stereoselective Synthesis of Butenolides and its Applications in Total Synthesis of Sessilifoliamides and Development of New Chemical Tools for Hydrogel Based Biomaterials.
Li, Yi.

Stereoselective Synthesis of Butenolides and its Applications in Total Synthesis of Sessilifoliamides and Development of New Chemical Tools for Hydrogel Based Biomaterials. - 1 online resource (264 pages)

Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.

Thesis (Ph.D.)--University of Delaware, 2017.

Includes bibliographical references

Allyl cyclopropene carboxylates undergo ring expansion reaction to give alloxyfuran intermediates, which can further rearrange to Deltabeta, gamma butenolides via Claisen rearrangement or Deltaalpha, beta butenolides via a further Cope rearrangement. These reactions display catalyst dependent regioselectivity and is stereospecific. The transition state was proposed and supported by absolute stereochemistry assignment. This method was applied to the total synthesis of dehydro-sessilifoliamide C. It features an one step installation of all the connectivities and a short and efficient synthesis of the cyclopropene carboxylate. Attempts to prepare sessilifoliamide B by hydrogenation were unsuccessful.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355260366Subjects--Topical Terms:

1148722
Organic chemistry.
Index Terms--Genre/Form:

554714
Electronic books.

Stereoselective Synthesis of Butenolides and its Applications in Total Synthesis of Sessilifoliamides and Development of New Chemical Tools for Hydrogel Based Biomaterials.
LDR:02660ntm a2200337K 4500 001 914110
005 20180703084421.5
006 m o u
007 cr mn||||a|a||
008 190606s2017 xx obm 000 0 eng d
020 $a 9780355260366
035 $a (MiAaPQ)AAI10263124
035 $a (MiAaPQ)udel:12799
035 $a AAI10263124
040 $a MiAaPQ $b eng $c MiAaPQ
100 1 $a Li, Yi. $3 561722
245 1 0 $a Stereoselective Synthesis of Butenolides and its Applications in Total Synthesis of Sessilifoliamides and Development of New Chemical Tools for Hydrogel Based Biomaterials.
264 0 $c 2017
300 $a 1 online resource (264 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.
500 $a Adviser: Joseph Fox.
502 $a Thesis (Ph.D.)--University of Delaware, 2017.
504 $a Includes bibliographical references
520 $a Allyl cyclopropene carboxylates undergo ring expansion reaction to give alloxyfuran intermediates, which can further rearrange to Deltabeta, gamma butenolides via Claisen rearrangement or Deltaalpha, beta butenolides via a further Cope rearrangement. These reactions display catalyst dependent regioselectivity and is stereospecific. The transition state was proposed and supported by absolute stereochemistry assignment. This method was applied to the total synthesis of dehydro-sessilifoliamide C. It features an one step installation of all the connectivities and a short and efficient synthesis of the cyclopropene carboxylate. Attempts to prepare sessilifoliamide B by hydrogenation were unsuccessful.
520 $a The third chapter describes a collaborative research on the development of biomaterial for cell culture purpose using tetrazine ligation. The chapter describes the development of chemical tools for the hydrogel preparation. The mechanical properties of hydrogels were controlled by introducing capping groups alongside crosslinker molecules in interfacial crosslinking events. Enzyme degradable crosslinkers and cell adhesive signals are prepared and introduced to the gels. It was shown by my collaborator that all the newly developed chemical tools can be incorporated in to the HA-Tz based hydrogels and NIH 3T3 cells can be cultured in the system with good viability and morphology.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Organic chemistry. $3 1148722
650 4 $a Materials science. $3 557839
655 7 $a Electronic books. $2 local $3 554714
690 $a 0490
690 $a 0794
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Delaware. $b Chemistry and Biochemistry. $3 1187217
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10263124 $z click for full text (PQDT)