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Structural Characteristics and Corrosion Behavior of Bio-Degradable Zn-Li Alloys in Stent Application.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Structural Characteristics and Corrosion Behavior of Bio-Degradable Zn-Li Alloys in Stent Application./
Author:	Zhao, Shan.
Description:	1 online resource (128 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
Subject:	Materials science. -
Online resource:	click for full text (PQDT)
ISBN:	9781369820447

Structural Characteristics and Corrosion Behavior of Bio-Degradable Zn-Li Alloys in Stent Application.
Zhao, Shan.

Structural Characteristics and Corrosion Behavior of Bio-Degradable Zn-Li Alloys in Stent Application. - 1 online resource (128 pages)

Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.

Thesis (Ph.D.)--Michigan Technological University, 2017.

Includes bibliographical references

Zinc has begun to be studied as a bio-degradable material in recent years due to its excellent corrosion rate and optimal biocompatibility. Unfortunately, pure Zn's intrinsic ultimate tensile strength (UTS; below 120 MPa) is lower than the benchmark (about 300 MPa) for cardiovascular stent materials, raising concerns about sufficient strength to support the blood vessel. Thus, modifying pure Zn to improve its mechanical properties is an important research topic. In this dissertation project, a new Zn-Li alloy has been developed to retain the outstanding corrosion behavior from Zn while improving the mechanical characteristics and uniform biodegradation once it is implanted into the artery of Sprague-Dawley rats. The completed work includes:

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369820447Subjects--Topical Terms:

557839
Materials science.
Index Terms--Genre/Form:

554714
Electronic books.

Structural Characteristics and Corrosion Behavior of Bio-Degradable Zn-Li Alloys in Stent Application.
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245 1 0 $a Structural Characteristics and Corrosion Behavior of Bio-Degradable Zn-Li Alloys in Stent Application.
264 0 $c 2017
300 $a 1 online resource (128 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
500 $a Advisers: Jaroslaw W. Drelich; Jeremy Goldman.
502 $a Thesis (Ph.D.)--Michigan Technological University, 2017.
504 $a Includes bibliographical references
520 $a Zinc has begun to be studied as a bio-degradable material in recent years due to its excellent corrosion rate and optimal biocompatibility. Unfortunately, pure Zn's intrinsic ultimate tensile strength (UTS; below 120 MPa) is lower than the benchmark (about 300 MPa) for cardiovascular stent materials, raising concerns about sufficient strength to support the blood vessel. Thus, modifying pure Zn to improve its mechanical properties is an important research topic. In this dissertation project, a new Zn-Li alloy has been developed to retain the outstanding corrosion behavior from Zn while improving the mechanical characteristics and uniform biodegradation once it is implanted into the artery of Sprague-Dawley rats. The completed work includes:
520 $a Manufactured Zn-Li alloy ingots and sheets via induction vacuum casting, melt spinning, hot rolling deformation, and wire electro discharge machining (wire EDM) technique; processed alloy samples using cross sectioning, mounting, etching and polishing technique; • Characterized alloy ingots, sheets and wires using hardness and tensile test, XRD, BEI imaging, SEM, ESEM, FTIR, ICP-OES and electrochemical test; then selected the optimum composition for in vitro and in vivo experiments; • Mimicked the degradation behavior of the Zn-Li alloy in vitro using simulated body fluid (SBF) and explored the relations between corrosion rate, corrosion products and surface morphology with changing compositions; • Explanted the Zn-Li alloy wire in abdominal aorta of rat over 12 months and studied its degradation mechanism, rate of bioabsorption, cytotoxicity and corrosion product migration from histological analysis.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Materials science. $3 557839
655 7 $a Electronic books. $2 local $3 554714
690 $a 0794
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Michigan Technological University. $b Materials Science and Engineering. $3 1182428
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10266745 $z click for full text (PQDT)