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MITOCHONDRIAL BIOGENESIS WITHIN MOUS...

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MITOCHONDRIAL BIOGENESIS WITHIN MOUSE - CHINESE HAMSTER SOMATIC CELL HYBRIDS.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	MITOCHONDRIAL BIOGENESIS WITHIN MOUSE - CHINESE HAMSTER SOMATIC CELL HYBRIDS./
Author:	SOLUS, JOSEPH FRANCIS.
Description:	1 online resource (177 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 44-09, Section: B, page: 2636.
Subject:	Biology. -
Online resource:	click for full text (PQDT)

MITOCHONDRIAL BIOGENESIS WITHIN MOUSE - CHINESE HAMSTER SOMATIC CELL HYBRIDS.
SOLUS, JOSEPH FRANCIS.

MITOCHONDRIAL BIOGENESIS WITHIN MOUSE - CHINESE HAMSTER SOMATIC CELL HYBRIDS. - 1 online resource (177 pages)

Source: Dissertation Abstracts International, Volume: 44-09, Section: B, page: 2636.

Thesis (Ph.D.)--Yale University, 1983.

Includes bibliographical references

Interspecific somatic cell hybrids were constructed from cell lines resistant to antibiotics inhibitory to mitochondrial function. Individual hybrid cultures were isolated in the presence of these antibiotics. The species of mitochondrial genomes present within each culture were determined by utilizing restriction endonuclease and nucleic acid hybridization techniques.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

Subjects--Topical Terms:

599573
Biology.
Index Terms--Genre/Form:

554714
Electronic books.

MITOCHONDRIAL BIOGENESIS WITHIN MOUSE - CHINESE HAMSTER SOMATIC CELL HYBRIDS.
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100 1 $a SOLUS, JOSEPH FRANCIS. $3 1187885
245 1 0 $a MITOCHONDRIAL BIOGENESIS WITHIN MOUSE - CHINESE HAMSTER SOMATIC CELL HYBRIDS.
264 0 $c 1983
300 $a 1 online resource (177 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertation Abstracts International, Volume: 44-09, Section: B, page: 2636.
502 $a Thesis (Ph.D.)--Yale University, 1983.
504 $a Includes bibliographical references
520 $a Interspecific somatic cell hybrids were constructed from cell lines resistant to antibiotics inhibitory to mitochondrial function. Individual hybrid cultures were isolated in the presence of these antibiotics. The species of mitochondrial genomes present within each culture were determined by utilizing restriction endonuclease and nucleic acid hybridization techniques.
520 $a The transmission of parental resistance(s) to hybrid progeny occurred at a high rate and was accompanied by the retention of the mitochondrial DNA species of the resistant parent(s). Antibiotic-mediated selection for parental resistance markers effectively influenced the observed segregation of parental mitochondrial genome populations within these hybrids.
520 $a These experiments have led to the generation of cell hybrids which propagate either or both parental mitochondrial genome population(s) under the supervision of hybrid nuclear machinery. The incorporation of active genetic markers affecting mitochondrial function into hybrids and the utilization of such markers to influence the mitochondrial population within these hybrids establishes an approach to the study of mitochondrial genetics and mitochondrial biogenesis within cultured mammalian cell lines.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biology. $3 599573
655 7 $a Electronic books. $2 local $3 554714
690 $a 0306
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Yale University. $3 1178968
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8329318 $z click for full text (PQDT)

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