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PROSTACYCLIN AND THROMBOXANE A(,2) IN THE DIABETIC CHINESE HAMSTER (BLOOD PLATELETS).

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	PROSTACYCLIN AND THROMBOXANE A(,2) IN THE DIABETIC CHINESE HAMSTER (BLOOD PLATELETS)./
Author:	SIMON, DAVID M.
Description:	1 online resource (124 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 46-05, Section: B, page: 1525.
Subject:	Pharmacology. -
Online resource:	click for full text (PQDT)

PROSTACYCLIN AND THROMBOXANE A(,2) IN THE DIABETIC CHINESE HAMSTER (BLOOD PLATELETS).
SIMON, DAVID M.

PROSTACYCLIN AND THROMBOXANE A(,2) IN THE DIABETIC CHINESE HAMSTER (BLOOD PLATELETS). - 1 online resource (124 pages)

Source: Dissertation Abstracts International, Volume: 46-05, Section: B, page: 1525.

Thesis (Ph.D.)--Rush University, College of Health Sciences, 1985.

Includes bibliographical references

The high incidence of vascular disease in patients with diabetes mellitus may be accounted for by an imbalance between platelet thromboxane (TX) synthesis and vascular prostacyclin (PGI(,2)) production. The influence of spontaneous diabetes, as seen in the Chinese hamster, on washed platelet TX synthesis, aggregation and vascular PGI(,2) synthesis was investigated using bioassay and radioimmunossay (RIA) techniques.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

Subjects--Topical Terms:

583819
Pharmacology.
Index Terms--Genre/Form:

554714
Electronic books.

PROSTACYCLIN AND THROMBOXANE A(,2) IN THE DIABETIC CHINESE HAMSTER (BLOOD PLATELETS).
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100 1 $a SIMON, DAVID M. $3 1187971
245 1 0 $a PROSTACYCLIN AND THROMBOXANE A(,2) IN THE DIABETIC CHINESE HAMSTER (BLOOD PLATELETS).
264 0 $c 1985
300 $a 1 online resource (124 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
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500 $a Source: Dissertation Abstracts International, Volume: 46-05, Section: B, page: 1525.
502 $a Thesis (Ph.D.)--Rush University, College of Health Sciences, 1985.
504 $a Includes bibliographical references
520 $a The high incidence of vascular disease in patients with diabetes mellitus may be accounted for by an imbalance between platelet thromboxane (TX) synthesis and vascular prostacyclin (PGI(,2)) production. The influence of spontaneous diabetes, as seen in the Chinese hamster, on washed platelet TX synthesis, aggregation and vascular PGI(,2) synthesis was investigated using bioassay and radioimmunossay (RIA) techniques.
520 $a Washed diabetic platelets demonstrated an increased aggregation response to arachidonic acid (AA). The Ed(,50) for AA to induce platelet aggregation was 1.9 x 10('-6) M for diabetic platelets and 8.7 x 10('-6) M for control platelets. At a dose range of 10('-7) to 10('-4) M AA, washed platelets from diabetic hamsters produced from 37% to 124% more TA(,2) than did control platelets. Thrombin (0.05 - 1.00 units/ml) induced platelet TX production was 96% to 177% higher in platelet samples from diabetic hamsters, although no difference in aggregation was observed.
520 $a Using in vitro bioassay techniques, diabetic aortas produced 9.2 (+OR-) 2.1 ng/mg tissue of PGI(,2) activity compared to 3.6 (+OR-) 0.9 ng/mg tissue produced by control aortas (p < 0.02). These data were confirmed using a specific RIA for the stable PGI(,2) metabolite, 6-keto PGF(,1)-alpha. Renal cortex specimens excised from diabetic hamsters produced decreased quantities of 6-keto PGF(,1)-alpha compared to control renal cortex. (Diabetic 0.26 (+OR-) 0.08 ng/mg tissue, control 0.34 (+OR-) 0.09 ng/mg tissue, x (+OR-) SEM, N = 6, p < 0.05.).
520 $a These results indicate that diabetic Chinese hamster AA metabolism is enhanced leading to increases in platelet TX and aortic PGI(,2) production. However, PGI(,2) production in renal cortex is depressed, indicating regional differences in AA metabolism.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Pharmacology. $3 583819
655 7 $a Electronic books. $2 local $3 554714
690 $a 0419
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Rush University, College of Health Sciences. $3 1187972
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8514210 $z click for full text (PQDT)