國立虎尾科技大學 |

Deep Learning on Biological Knowledge Graphs.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Deep Learning on Biological Knowledge Graphs./
作者:	Maddouri, Omar.
面頁冊數:	1 online resource (99 pages)
附註:	Source: Masters Abstracts International, Volume: 56-04.
標題:	Computer science. -
電子資源:	click for full text (PQDT)
ISBN:	9781369804980

Deep Learning on Biological Knowledge Graphs.
Maddouri, Omar.

Deep Learning on Biological Knowledge Graphs. - 1 online resource (99 pages)

Source: Masters Abstracts International, Volume: 56-04.

Thesis (M.S.)--Hamad Bin Khalifa University (Qatar), 2017.

Includes bibliographical references

Biological data and knowledge bases are increasingly relying on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. Over the last decade, feature learning methods that are applicable to graph-structured data are becoming available, but have not yet widely been applied and evaluated on structured biological knowledge. In this thesis, we have developed a novel method for feature learning on biological knowledge graphs. Our method combines symbolic methods, in particular knowledge representation using symbolic logic and automated reasoning, with neural networks to generate node representations (embeddings) that encode for related information within knowledge graphs. Through the use of symbolic logic, we have shown that these embeddings contain both explicit and implicit information. We have applied these embeddings to the prediction of edges in the knowledge graph representing problems of function prediction, finding candidate genes of diseases, protein-protein interactions, or drug target relations. Similarly, we have learned and applied our embeddings to the prediction of disease comorbidities in an additional knowledge graph designed for this purpose and centered on disease instances. Importantly, our approach have demonstrated a performance that matches and sometimes outperforms traditional approaches based on manually crafted features. Interestingly, our method can be applied to any biological knowledge graph, and will thereby open up the increasing amount of Semantic Web based knowledge databases in biology and will expand its usage in machine learning and data analytics.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369804980Subjects--Topical Terms:

573171
Computer science.
Index Terms--Genre/Form:

554714
Electronic books.

Deep Learning on Biological Knowledge Graphs.
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500 $a Source: Masters Abstracts International, Volume: 56-04.
500 $a Advisers: Imed Gallouzi; Robert Hoehndorf.
502 $a Thesis (M.S.)--Hamad Bin Khalifa University (Qatar), 2017.
504 $a Includes bibliographical references
520 $a Biological data and knowledge bases are increasingly relying on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. Over the last decade, feature learning methods that are applicable to graph-structured data are becoming available, but have not yet widely been applied and evaluated on structured biological knowledge. In this thesis, we have developed a novel method for feature learning on biological knowledge graphs. Our method combines symbolic methods, in particular knowledge representation using symbolic logic and automated reasoning, with neural networks to generate node representations (embeddings) that encode for related information within knowledge graphs. Through the use of symbolic logic, we have shown that these embeddings contain both explicit and implicit information. We have applied these embeddings to the prediction of edges in the knowledge graph representing problems of function prediction, finding candidate genes of diseases, protein-protein interactions, or drug target relations. Similarly, we have learned and applied our embeddings to the prediction of disease comorbidities in an additional knowledge graph designed for this purpose and centered on disease instances. Importantly, our approach have demonstrated a performance that matches and sometimes outperforms traditional approaches based on manually crafted features. Interestingly, our method can be applied to any biological knowledge graph, and will thereby open up the increasing amount of Semantic Web based knowledge databases in biology and will expand its usage in machine learning and data analytics.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Computer science. $3 573171
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