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Patent Ductus Arteriosus Ligation in...
~
Weisz, Dany.
Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment./
作者:
Weisz, Dany.
面頁冊數:
1 online resource (132 pages)
附註:
Source: Masters Abstracts International, Volume: 56-03.
標題:
Medicine. -
電子資源:
click for full text (PQDT)
ISBN:
9781369666489
Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
Weisz, Dany.
Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
- 1 online resource (132 pages)
Source: Masters Abstracts International, Volume: 56-03.
Thesis (M.Sc.)--University of Toronto (Canada), 2016.
Includes bibliographical references
Objective: Evaluate the association between patent ductus arteriosus (PDA) ligation vs. medical management and neonatal and neurodevelopmental outcomes.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018
Mode of access: World Wide Web
ISBN: 9781369666489Subjects--Topical Terms:
644133
Medicine.
Index Terms--Genre/Form:
554714
Electronic books.
Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
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Source: Masters Abstracts International, Volume: 56-03.
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Adviser: Prakesh S. Shah.
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Thesis (M.Sc.)--University of Toronto (Canada), 2016.
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Includes bibliographical references
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Objective: Evaluate the association between patent ductus arteriosus (PDA) ligation vs. medical management and neonatal and neurodevelopmental outcomes.
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Methods: Retrospective cohort study of extremely preterm infants with PDA born between 2006-2012. The primary outcome was death or neurodevelopmental impairment (NDI) at 18-24 months. Secondary outcomes included death, chronic lung disease (CLD), and NDI. Multivariable logistic regression (MLR) analysis and marginal structural models (MSM) were used to adjust for perinatal and postnatal confounders.
520
$a
Results: Of 754 infants with PDA, 184(24%) underwent ligation. Compared with medically treated infants, ligated infants had similar odds of death/NDI (aOR 0.83, 95%CI:0.52-1.32), NDI (aOR 1.27, 95%CI:0.78--2.06), and CLD (aOR 1.36, 95%CI:0.78--2.39), but lower mortality (aOR 0.09, 95%CI:0.04--0.21).
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Conclusions: PDA ligation is not associated with adverse outcomes and may reduce mortality. Previously reported associations of ligation with increased morbidity are likely due to bias from confounding by indication, rather than a detrimental causal effect of ligation.
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click for full text (PQDT)
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