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MEMS-based thermal and mass-transport control for microfluidic biochemical reagent mixing and two-dimensional gas chromatography.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	MEMS-based thermal and mass-transport control for microfluidic biochemical reagent mixing and two-dimensional gas chromatography./
Author:	Kim, Sung Jin.
Description:	1 online resource (139 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 71-12, Section: B, page: 7669.
Contained By:	Dissertation Abstracts International71-12B.
Subject:	Mechanical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9781124280776

MEMS-based thermal and mass-transport control for microfluidic biochemical reagent mixing and two-dimensional gas chromatography.
Kim, Sung Jin.

MEMS-based thermal and mass-transport control for microfluidic biochemical reagent mixing and two-dimensional gas chromatography. - 1 online resource (139 pages)

Source: Dissertation Abstracts International, Volume: 71-12, Section: B, page: 7669.

Thesis (Ph.D.)--University of Michigan, 2010.

Includes bibliographical references

This research demonstrates the use of microelectromechanical systems (MEMS) technology to control microscale heat and mass transfer for lab-on-a-chip biochemical assays and the analysis of complex vapor mixtures. Toward this goal, we have developed two microdevices, namely (1) a micromixer and (2) a microthermal modulator. The micromixer uses natural convection to greatly simplify the micromixing process in a microfluidic network, whereas the microthermal modulator utilizes forced convection to manipulate vapor samples in a fast, low-power consuming manner within a comprehensive 2-D gas chromatography system.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781124280776Subjects--Topical Terms:

557493
Mechanical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

MEMS-based thermal and mass-transport control for microfluidic biochemical reagent mixing and two-dimensional gas chromatography.
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245 1 0 $a MEMS-based thermal and mass-transport control for microfluidic biochemical reagent mixing and two-dimensional gas chromatography.
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300 $a 1 online resource (139 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 71-12, Section: B, page: 7669.
500 $a Adviser: Katsuo Krabayashi.
502 $a Thesis (Ph.D.)--University of Michigan, 2010.
504 $a Includes bibliographical references
520 $a This research demonstrates the use of microelectromechanical systems (MEMS) technology to control microscale heat and mass transfer for lab-on-a-chip biochemical assays and the analysis of complex vapor mixtures. Toward this goal, we have developed two microdevices, namely (1) a micromixer and (2) a microthermal modulator. The micromixer uses natural convection to greatly simplify the micromixing process in a microfluidic network, whereas the microthermal modulator utilizes forced convection to manipulate vapor samples in a fast, low-power consuming manner within a comprehensive 2-D gas chromatography system.
520 $a In a microfluidic network, micromixing is a crucial step for biochemical analysis. A critical challenge is that the microfluidic systems need numerous chambers and channels not only for mixing but also for biochemical reactions and detections. Thus, a simple and compatible design of the micromixer element for the system is essential. Here, we demonstrate a simple, yet effective, scheme that enables micromixing and biochemical reaction in a single chamber without using any mechanical components. We accomplish this process by using natural convection in conjunction with two alternating heaters for micromixing. As a model application, we demonstrate PCR and its reagent mixing in a single microfluidic chamber. Our results will significantly simplify the micromixing and subsequent biochemical reactions.
520 $a In comprehensive two-dimensional gas chromatography (GCxGC), a modulator is placed at the juncture between two separation columns to focus and re-inject eluting mixture components, thereby enhancing the resolution and the sensitivity of the analysis. Here, we present the design, fabrication, thermal operation, and initial testing of a two-stage microscale thermal modulator (microTM). The microTM contains two sequential serpentine Pyrex-on-Si microchannels (stages) that cryogenically trap analytes eluting from the first-dimension column and thermally inject them into the second-dimension column in a rapid, programmable manner with low thermal crosstalk between the two stages. A lumped heat transfer model is used to analyze the device design with respect to the rates of heating and cooling, power dissipation, and inter-stage thermal. Preliminary tests using a conventional capillary column interfaced to the microTM demonstrate the modulation of a mixture of alkanes.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Mechanical engineering. $3 557493
650 4 $a Biomedical engineering. $3 588770
655 7 $a Electronic books. $2 local $3 554714
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690 $a 0541
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Michigan. $3 845400
773 0 $t Dissertation Abstracts International $g 71-12B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3429347 $z click for full text (PQDT)