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Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Blood flow patterns, arterial Reynolds number, exercise, and endothelial function./
Author:	Gurovich, Alvaro N.
Description:	1 online resource (138 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: 2613.
Contained By:	Dissertation Abstracts International72-05B.
Subject:	Physiology. -
Online resource:	click for full text (PQDT)
ISBN:	9781124514109

Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.
Gurovich, Alvaro N.

Blood flow patterns, arterial Reynolds number, exercise, and endothelial function. - 1 online resource (138 pages)

Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: 2613.

Thesis (Ph.D.)--University of Florida, 2010.

Includes bibliographical references

Endothelial dysfunction is the first pathophysiological step in atherosclerosis. It has been shown that exercise training improves endothelial function via direct effects on cardiovascular risk factors. However, direct effects of exercise-induced blood flow on endothelial function are controversial. We hypothesized that exercise training-induced endothelial function improvement is (1) systemic and not only localized in exercising vascular beds, and (2) that improved endothelial function is mediated by retrograde turbulent and antegrade laminar blood flow patterns. To test our central hypotheses, we designed three in-vivo experiments (1) to characterize beneficial blood flow patterns, (2) to characterize blood flow patterns during different exercise types and intensities, and (3) to determine possible mechanisms involved on endothelial function regulation produced by exercise-induced blood flow as a mechanical stimulus.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781124514109Subjects--Topical Terms:

673386
Physiology.
Index Terms--Genre/Form:

554714
Electronic books.

Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.
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100 1 $a Gurovich, Alvaro N. $3 1189592
245 1 0 $a Blood flow patterns, arterial Reynolds number, exercise, and endothelial function.
264 0 $c 2010
300 $a 1 online resource (138 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
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500 $a Source: Dissertation Abstracts International, Volume: 72-05, Section: B, page: 2613.
500 $a Includes supplementary digital materials.
500 $a Adviser: Randy W. Braith.
502 $a Thesis (Ph.D.)--University of Florida, 2010.
504 $a Includes bibliographical references
520 $a Endothelial dysfunction is the first pathophysiological step in atherosclerosis. It has been shown that exercise training improves endothelial function via direct effects on cardiovascular risk factors. However, direct effects of exercise-induced blood flow on endothelial function are controversial. We hypothesized that exercise training-induced endothelial function improvement is (1) systemic and not only localized in exercising vascular beds, and (2) that improved endothelial function is mediated by retrograde turbulent and antegrade laminar blood flow patterns. To test our central hypotheses, we designed three in-vivo experiments (1) to characterize beneficial blood flow patterns, (2) to characterize blood flow patterns during different exercise types and intensities, and (3) to determine possible mechanisms involved on endothelial function regulation produced by exercise-induced blood flow as a mechanical stimulus.
520 $a We recruited 53 apparently healthy, young men for the three studies (18 on the first, 8 on the second, and 27 for the third one) and the most relevant results showed (1) beneficial blood flows include two opposite patterns: antegrade laminar and retrograde turbulent; (2) retrograde turbulent blood flow is increased during cycling exercise in a dose-dependent manner; and (3) exercise-induced blood flow regulates endothelial function via a decrease on endothelial oxidative stress and increase on endothelial nitric oxide synthase.
520 $a These results provide, for the first time, evidence in support of the hypothesis that exercise-induced blood flow regulation of endothelial function is dependent upon blood flow pattern. In addition, these results provide further evidence of the close relationship between endothelial function, endothelial nitric oxide synthase, and endothelial cell oxidative stress in vivo. .
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Physiology. $3 673386
650 4 $a Kinesiology. $3 721210
655 7 $a Electronic books. $2 local $3 554714
690 $a 0719
690 $a 0575
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Florida. $3 845432
773 0 $t Dissertation Abstracts International $g 72-05B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3447043 $z click for full text (PQDT)