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Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis./
作者:	Jastrebski, Sara F.
面頁冊數:	1 online resource (91 pages)
附註:	Source: Masters Abstracts International, Volume: 57-01.
Contained By:	Masters Abstracts International57-01(E).
標題:	Animal sciences. -
電子資源:	click for full text (PQDT)
ISBN:	9780355465297

Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis.
Jastrebski, Sara F.

Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis. - 1 online resource (91 pages)

Source: Masters Abstracts International, Volume: 57-01.

Thesis (M.S.)--University of Delaware, 2017.

Includes bibliographical references

The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This makes it an important organ during times of heat, where the body is adjusting to hyperthermic stress. This study integrates transcriptomic and metabolomic data to understand how the chicken liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation. Our results yield valuable insight into how a chicken responds to hyperthermia. This is important because it creates a base for understanding how the chicken responds to heat stress and opens the door for future studies on how to potentially supplement chickens to alleviate problems they have during heat stress as well as help producers by creating a better producing bird that is not as severely impacted by heat stress.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355465297Subjects--Topical Terms:

1178863
Animal sciences.
Index Terms--Genre/Form:

554714
Electronic books.

Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis.
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245 1 0 $a Chicken Hepatic Response to Chronic Heat Stress Using Integrated Transcriptome and Metabolome Analysis.
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500 $a Source: Masters Abstracts International, Volume: 57-01.
500 $a Adviser: Carl J. Schmidt.
502 $a Thesis (M.S.)--University of Delaware, 2017.
504 $a Includes bibliographical references
520 $a The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This makes it an important organ during times of heat, where the body is adjusting to hyperthermic stress. This study integrates transcriptomic and metabolomic data to understand how the chicken liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation. Our results yield valuable insight into how a chicken responds to hyperthermia. This is important because it creates a base for understanding how the chicken responds to heat stress and opens the door for future studies on how to potentially supplement chickens to alleviate problems they have during heat stress as well as help producers by creating a better producing bird that is not as severely impacted by heat stress.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Animal sciences. $3 1178863
650 4 $a Genetics. $3 578972
650 4 $a Agriculture. $3 660421
655 7 $a Electronic books. $2 local $3 554714
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