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Is Fused Filament Fabrication a Viable Fabrication Method for Bioabsorbable Devices? Development of a 3D Printed Clip for Prevention of Spinal Fusion Infection.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Is Fused Filament Fabrication a Viable Fabrication Method for Bioabsorbable Devices? Development of a 3D Printed Clip for Prevention of Spinal Fusion Infection./
Author:	Schachtner, Jackie Theresia.
Description:	1 online resource (73 pages)
Notes:	Source: Masters Abstracts International, Volume: 58-01.
Contained By:	Masters Abstracts International58-01(E).
Subject:	Biomedical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9780438195387

Is Fused Filament Fabrication a Viable Fabrication Method for Bioabsorbable Devices? Development of a 3D Printed Clip for Prevention of Spinal Fusion Infection.
Schachtner, Jackie Theresia.

Is Fused Filament Fabrication a Viable Fabrication Method for Bioabsorbable Devices? Development of a 3D Printed Clip for Prevention of Spinal Fusion Infection. - 1 online resource (73 pages)

Source: Masters Abstracts International, Volume: 58-01.

Thesis (M.S.)--Drexel University, 2018.

Includes bibliographical references

Lower back pain impacts a majority of the world population at least once in their lifetime. The source of this pain is often due to degenerative changes in the lower spine, sometimes requiring surgical intervention in the form of lumbar spinal fusion. Surgical site infection (SSI) is a serious complication of spinal surgery, affecting as high as 8.5% of the patient population. If the SSI cannot be eradicated with intravenous antibiotic therapy, the next step is a second surgery, involving debridement of the wound and replacing the infected device. Additional surgery not only increases the cost imposed on the patient but also extends recovery time.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780438195387Subjects--Topical Terms:

588770
Biomedical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

Is Fused Filament Fabrication a Viable Fabrication Method for Bioabsorbable Devices? Development of a 3D Printed Clip for Prevention of Spinal Fusion Infection.
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100 1 $a Schachtner, Jackie Theresia. $3 1192738
245 1 0 $a Is Fused Filament Fabrication a Viable Fabrication Method for Bioabsorbable Devices? Development of a 3D Printed Clip for Prevention of Spinal Fusion Infection.
264 0 $c 2018
300 $a 1 online resource (73 pages)
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500 $a Source: Masters Abstracts International, Volume: 58-01.
500 $a Adviser: Steven M. Kurtz.
502 $a Thesis (M.S.)--Drexel University, 2018.
504 $a Includes bibliographical references
520 $a Lower back pain impacts a majority of the world population at least once in their lifetime. The source of this pain is often due to degenerative changes in the lower spine, sometimes requiring surgical intervention in the form of lumbar spinal fusion. Surgical site infection (SSI) is a serious complication of spinal surgery, affecting as high as 8.5% of the patient population. If the SSI cannot be eradicated with intravenous antibiotic therapy, the next step is a second surgery, involving debridement of the wound and replacing the infected device. Additional surgery not only increases the cost imposed on the patient but also extends recovery time.
520 $a In this study, an ultrasound triggered device for the dispersal of antibiotics, was developed as a potential solution. The device is constructed of a bioabsorbable polymer via fused filament fabrication (FFF). This device attaches to a standard 5.5 mm fusion rod and will degrade in vivo. Initially, a literature review was performed to determine the most appropriate polymer for this device. Poly-L-co-D,L-lactic acid (PLDLLA) 70/30 was chosen and a filament was fabricated. Gel permeation chromatography (GPC) and differential scanning calorimetry (DSC) analysis were performed to determine the molecular weight and thermal properties of the filament. The filaments were found to be consistent in molecular weight and thermal properties (p = 0.348 and p = 0.487, respectively). Once analyzed, the filament was then used for FFF printing. Initially, 1cm3 cubes were printed for optimization of printing parameters such as print speed and layer height. Then, printing of the spinal clip was attempted. Slight modifications were made to the clip design and printing parameters to reach the final product. Dimensional accuracy was assessed using microCT analysis. There was a difference between the thickness of the printed clip and the intended design (p = 0.029). All other dimensions were found to be similar. To assess the degradation, the clips were incubated at 37°C in PBS for a month and mass loss was measured at one-week time points. Additionally, raw pellets of PLDLLA 70/30 and the filament were degraded, and mass loss was assessed to evaluate how melting the material multiple times impacted the degradation properties. Degradation rate was found to be similar among the samples throughout the first three weeks of degradation however, the raw pellets were found to degrade at a slower rate by the final week (p = 0.039).
520 $a Further research should focus on additional print optimization as well as determination of the device coating method. Currently, the procedure for device coating involves dipping the device in PLA to create a thin film, but this has proven to result in a coating that is too thick to rupture with ultrasound. The next step would be to formulate a 3D printed coating option to optimize the coating thickness. This study demonstrated a promising future for this device and the viability of not only FFF with PLDLLA but other bioabsorbable polymers, increasing the reach of personalized medicine.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biomedical engineering. $3 588770
650 4 $a Materials science. $3 557839
655 7 $a Electronic books. $2 local $3 554714
690 $a 0541
690 $a 0794
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Drexel University. $b Biomedical Engineering (School of Biomedical Engineering, Science, and Health Systems). $3 1192739
773 0 $t Masters Abstracts International $g 58-01(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10829126 $z click for full text (PQDT)