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Chemotherapy for Cancer and the Agin...
~
Morin, Ruth T.
Chemotherapy for Cancer and the Aging Brain : = Blessing or Burden?
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
Chemotherapy for Cancer and the Aging Brain :/
其他題名:
Blessing or Burden?
作者:
Morin, Ruth T.
面頁冊數:
1 online resource (88 pages)
附註:
Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
Contained By:
Dissertation Abstracts International79-03B(E).
標題:
Clinical psychology. -
電子資源:
click for full text (PQDT)
ISBN:
9780355306828
Chemotherapy for Cancer and the Aging Brain : = Blessing or Burden?
Morin, Ruth T.
Chemotherapy for Cancer and the Aging Brain :
Blessing or Burden? - 1 online resource (88 pages)
Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
Thesis (Ph.D.)--Columbia University, 2017.
Includes bibliographical references
Purpose: The proportion of the United States population in older adulthood is growing rapidly, and with that growth comes an increase in diseases such as cancer. As rates of illness increase, there is a concomitant increase in cognitive and psychological correlates of illnesses like cancer. There is evidence that some cancer treatments, particularly chemotherapy, affect cognition for cancer patients, although these results are inconsistent. Additionally, depression, and other health factors such as activities of daily living (ADLs) have been found to relate to cognitive impairment among older adults with cancer. Method: The current study used latent class growth analysis (LCGA) to explore longitudinal data from the Health and Retirement Study. The primary goal was to investigate possible trajectories of cognitive functioning in older adults diagnosed with, and surviving cancer. Possible psychological, health, and demographic predictors of membership in these cognitive trajectories were investigated. Results: Findings indicated that three classes of cognitive functioning best fit the data: these were High Recall, Middle Recall and Low Recall Classes, which represented fairly stable trajectories from pre-diagnosis to a period four years later. Various covariates of class membership were included in the analyses. Treatment with chemotherapy significantly predicted membership in the High Recall Class, however this finding is accounted for by an interaction with younger age. More symptoms of depression after diagnosis (but not prior to diagnosis) were significantly predictive of membership in the Low Recall Class. A higher self-reported probability of living to the age of 85 pre-diagnosis predicted membership in the High Recall Class, and greater difficulty with ADLs post-diagnosis predicted membership in the Low Recall Class. Finally, individuals in the High Recall Class were significantly more likely to be younger, female, and more highly educated, when compared to both the Middle and Low Recall Classes. Limitations: The current study is limited by the wide spacing of data collection and dearth of sensitive and varied measures of cognitive functioning, which in turn limits the generalizability and specificity of the findings. Additionally, a lack of data on cancer type, staging and treatment variables make more nuanced analysis difficult. It is not possible to generalize these findings to individuals who passed away within two years of their diagnosis, not to individuals of minority status, who were underrepresented in this sample. Conclusions: These results may inform the understanding of cognitive functioning in older adults surviving cancer, as it relates to psychological, demographic and other health factors, with implications for timing and targeting of interventions.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018
Mode of access: World Wide Web
ISBN: 9780355306828Subjects--Topical Terms:
649607
Clinical psychology.
Index Terms--Genre/Form:
554714
Electronic books.
Chemotherapy for Cancer and the Aging Brain : = Blessing or Burden?
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Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
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Purpose: The proportion of the United States population in older adulthood is growing rapidly, and with that growth comes an increase in diseases such as cancer. As rates of illness increase, there is a concomitant increase in cognitive and psychological correlates of illnesses like cancer. There is evidence that some cancer treatments, particularly chemotherapy, affect cognition for cancer patients, although these results are inconsistent. Additionally, depression, and other health factors such as activities of daily living (ADLs) have been found to relate to cognitive impairment among older adults with cancer. Method: The current study used latent class growth analysis (LCGA) to explore longitudinal data from the Health and Retirement Study. The primary goal was to investigate possible trajectories of cognitive functioning in older adults diagnosed with, and surviving cancer. Possible psychological, health, and demographic predictors of membership in these cognitive trajectories were investigated. Results: Findings indicated that three classes of cognitive functioning best fit the data: these were High Recall, Middle Recall and Low Recall Classes, which represented fairly stable trajectories from pre-diagnosis to a period four years later. Various covariates of class membership were included in the analyses. Treatment with chemotherapy significantly predicted membership in the High Recall Class, however this finding is accounted for by an interaction with younger age. More symptoms of depression after diagnosis (but not prior to diagnosis) were significantly predictive of membership in the Low Recall Class. A higher self-reported probability of living to the age of 85 pre-diagnosis predicted membership in the High Recall Class, and greater difficulty with ADLs post-diagnosis predicted membership in the Low Recall Class. Finally, individuals in the High Recall Class were significantly more likely to be younger, female, and more highly educated, when compared to both the Middle and Low Recall Classes. Limitations: The current study is limited by the wide spacing of data collection and dearth of sensitive and varied measures of cognitive functioning, which in turn limits the generalizability and specificity of the findings. Additionally, a lack of data on cancer type, staging and treatment variables make more nuanced analysis difficult. It is not possible to generalize these findings to individuals who passed away within two years of their diagnosis, not to individuals of minority status, who were underrepresented in this sample. Conclusions: These results may inform the understanding of cognitive functioning in older adults surviving cancer, as it relates to psychological, demographic and other health factors, with implications for timing and targeting of interventions.
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