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The Biomechanics of Pregnancy : = Simulating Pregnancy Mechanics, Evaluating Preterm Delivery Interventions, and Measuring in-vivo Mechanical Properties.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	The Biomechanics of Pregnancy :/
其他題名:	Simulating Pregnancy Mechanics, Evaluating Preterm Delivery Interventions, and Measuring in-vivo Mechanical Properties.
作者:	Fernandez, Michael.
面頁冊數:	1 online resource (155 pages)
附註:	Source: Dissertation Abstracts International, Volume: 78-04(E), Section: B.
Contained By:	Dissertation Abstracts International78-04B(E).
標題:	Mechanical engineering. -
電子資源:	click for full text (PQDT)
ISBN:	9781369342475

The Biomechanics of Pregnancy : = Simulating Pregnancy Mechanics, Evaluating Preterm Delivery Interventions, and Measuring in-vivo Mechanical Properties.
Fernandez, Michael.

The Biomechanics of Pregnancy :Simulating Pregnancy Mechanics, Evaluating Preterm Delivery Interventions, and Measuring in-vivo Mechanical Properties. - 1 online resource (155 pages)

Source: Dissertation Abstracts International, Volume: 78-04(E), Section: B.

Thesis (Ph.D.)--Columbia University, 2017.

Includes bibliographical references

Preterm birth is a public health problem affecting almost 15 million newborns each year, with almost one million cases annually being fatal. Despite many decades of research, identifying high-risk pregnancies remains difficult. Even with the therapies currently available to clinicians, 95% of preterm births are seemingly intractable. We see a great opportunity for engineers to collaborate with clinicians to help reduce the adverse health impact of this phenomenon. This work is a multi-faceted contribution to the study of the biomechanical problem of preterm birth. We portray the successful, full-term, pregnancy as a delicate balance of organ geometry, tissue deformation behavior, and the physical interaction between the uterus, cervix, and fetal membranes. The cervix is our focus, as its preterm ripening and dilation are the final pathway to premature delivery. We consider a selection of geometric and material factors, studying their impact on the loading that occurs in the cervix. We also study the mechanical implications of the use of a cervical pessary on the mechanical environment of pregnancy. Our mechanical analyses use a custom parameterized model of the pregnant anatomy, coupled with Finite Element Analysis techniques, to allow for rapid model development. In addition, we present a push towards the in-vivo measurement of cervical material properties by way of a phantom study using modern MRI techniques.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369342475Subjects--Topical Terms:

557493
Mechanical engineering.
Index Terms--Genre/Form:

554714
Electronic books.

The Biomechanics of Pregnancy : = Simulating Pregnancy Mechanics, Evaluating Preterm Delivery Interventions, and Measuring in-vivo Mechanical Properties.
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504 $a Includes bibliographical references
520 $a Preterm birth is a public health problem affecting almost 15 million newborns each year, with almost one million cases annually being fatal. Despite many decades of research, identifying high-risk pregnancies remains difficult. Even with the therapies currently available to clinicians, 95% of preterm births are seemingly intractable. We see a great opportunity for engineers to collaborate with clinicians to help reduce the adverse health impact of this phenomenon. This work is a multi-faceted contribution to the study of the biomechanical problem of preterm birth. We portray the successful, full-term, pregnancy as a delicate balance of organ geometry, tissue deformation behavior, and the physical interaction between the uterus, cervix, and fetal membranes. The cervix is our focus, as its preterm ripening and dilation are the final pathway to premature delivery. We consider a selection of geometric and material factors, studying their impact on the loading that occurs in the cervix. We also study the mechanical implications of the use of a cervical pessary on the mechanical environment of pregnancy. Our mechanical analyses use a custom parameterized model of the pregnant anatomy, coupled with Finite Element Analysis techniques, to allow for rapid model development. In addition, we present a push towards the in-vivo measurement of cervical material properties by way of a phantom study using modern MRI techniques.
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