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The Statistical Dynamics of Nonequilibrium Control.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	The Statistical Dynamics of Nonequilibrium Control./
Author:	Rotskoff, Grant Murray.
Description:	1 online resource (132 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
Contained By:	Dissertation Abstracts International78-11B(E).
Subject:	Physics. -
Online resource:	click for full text (PQDT)
ISBN:	9781369881202

The Statistical Dynamics of Nonequilibrium Control.
Rotskoff, Grant Murray.

The Statistical Dynamics of Nonequilibrium Control. - 1 online resource (132 pages)

Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.

Thesis (Ph.D.)--University of California, Berkeley, 2017.

Includes bibliographical references

Living systems, even at the scale of single molecules, are constantly adapting to changing environmental conditions. The physical response of a nanoscale system to external gradients or changing thermodynamic conditions can be chaotic, nonlinear, and hence difficult to control or predict. Nevertheless, biology has evolved systems that reliably carry out the cell's vital functions efficiently enough to ensure survival. Moreover, the development of new experimental techniques to monitor and manipulate single biological molecules has provided a natural testbed for theoretical investigations of nonequilibrium dynamics. This work focuses on developing paradigms for both understanding the principles of nonequilibrium dynamics and also for controlling such systems in the presence of thermal fluctuations.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369881202Subjects--Topical Terms:

564049
Physics.
Index Terms--Genre/Form:

554714
Electronic books.

The Statistical Dynamics of Nonequilibrium Control.
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100 1 $a Rotskoff, Grant Murray. $3 1193214
245 1 4 $a The Statistical Dynamics of Nonequilibrium Control.
264 0 $c 2017
300 $a 1 online resource (132 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
500 $a Adviser: Phillip L. Geissler.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2017.
504 $a Includes bibliographical references
520 $a Living systems, even at the scale of single molecules, are constantly adapting to changing environmental conditions. The physical response of a nanoscale system to external gradients or changing thermodynamic conditions can be chaotic, nonlinear, and hence difficult to control or predict. Nevertheless, biology has evolved systems that reliably carry out the cell's vital functions efficiently enough to ensure survival. Moreover, the development of new experimental techniques to monitor and manipulate single biological molecules has provided a natural testbed for theoretical investigations of nonequilibrium dynamics. This work focuses on developing paradigms for both understanding the principles of nonequilibrium dynamics and also for controlling such systems in the presence of thermal fluctuations.
520 $a Throughout this work, I rely on a perspective based on two central ideas in nonequilibrium statistical mechanics: large deviation theory, which provides a formalism akin to thermodynamics for nonequilibrium systems, and the fluctuation theorems which identify time symmetry breaking with entropy production. I use the tools of large deviation theory to explore concepts like efficiency and optimal coarse-graining in microscopic dynamical systems. The results point to the extreme importance of rare events in nonequilibrium dynamics. In the context of rare dynamical events, I outline a formal approach to predict efficient control protocols for nonequilibrium systems and develop computational tools to solve the resulting high dimensional optimization problems. The final chapters of this work focus on applications to self-assembly dynamics. I show that the yield of desired structures can be enhanced by driving a system away from equilibrium, using analysis inspired by the theory of the hydrophobic effect. Finally, I demonstrate that nanoscale, protein shells can be modeled and controlled to robustly produce monodisperse, nonequilibrium structures strikingly similar to the microcompartments observed in a variety of bacteria.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Physics. $3 564049
650 4 $a Condensed matter physics. $3 1148471
650 4 $a Biophysics. $3 581576
655 7 $a Electronic books. $2 local $3 554714
690 $a 0605
690 $a 0611
690 $a 0786
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, Berkeley. $b Biophysics. $3 1193215
773 0 $t Dissertation Abstracts International $g 78-11B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10280185 $z click for full text (PQDT)