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Regulation of Transcriptional Machinery and Its Relationship to Disease.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Regulation of Transcriptional Machinery and Its Relationship to Disease./
Author:	Bruning, John.
Description:	1 online resource (178 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
Contained By:	Dissertation Abstracts International79-01B(E).
Subject:	Biophysics. -
Online resource:	click for full text (PQDT)
ISBN:	9780355143140

Regulation of Transcriptional Machinery and Its Relationship to Disease.
Bruning, John.

Regulation of Transcriptional Machinery and Its Relationship to Disease. - 1 online resource (178 pages)

Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2017.

Includes bibliographical references

Transcription is the process in which our genetic information in the form of DNA is first utilized to create the machinery, structural integrity, and regulatory components that allows for cells to simply survive. While there are many, many, many regulatory modes and mechanisms that govern processes from enzyme catalysis to cell differentiation (and everything in between), the regulation of transcription is the initial decision to 'put the players on the pitch.' Transcriptional regulation is immensely complex, as it rightfully should be, as it is required for both simple procedures, for example simply increasing the mRNA copy number of a single species in response to a cellular cue, to intricately coordinated events such as decisions regarding cell fate. Transcription factors are the protein components that interplay between environmental cues and gene expression. In particular, nuclear receptors are ligand dependent transcription factors that are modulated by a small molecule ligand which provides information about a particular metabolic pathway. The focus of my research has been a biochemical and structural understanding of how this subset of transcriptional machinery is implicated in the etiology of disease.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355143140Subjects--Topical Terms:

581576
Biophysics.
Index Terms--Genre/Form:

554714
Electronic books.

Regulation of Transcriptional Machinery and Its Relationship to Disease.
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245 1 0 $a Regulation of Transcriptional Machinery and Its Relationship to Disease.
264 0 $c 2017
300 $a 1 online resource (178 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
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500 $a Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
500 $a Adviser: Matthew P. Jacobson.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2017.
504 $a Includes bibliographical references
520 $a Transcription is the process in which our genetic information in the form of DNA is first utilized to create the machinery, structural integrity, and regulatory components that allows for cells to simply survive. While there are many, many, many regulatory modes and mechanisms that govern processes from enzyme catalysis to cell differentiation (and everything in between), the regulation of transcription is the initial decision to 'put the players on the pitch.' Transcriptional regulation is immensely complex, as it rightfully should be, as it is required for both simple procedures, for example simply increasing the mRNA copy number of a single species in response to a cellular cue, to intricately coordinated events such as decisions regarding cell fate. Transcription factors are the protein components that interplay between environmental cues and gene expression. In particular, nuclear receptors are ligand dependent transcription factors that are modulated by a small molecule ligand which provides information about a particular metabolic pathway. The focus of my research has been a biochemical and structural understanding of how this subset of transcriptional machinery is implicated in the etiology of disease.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biophysics. $3 581576
655 7 $a Electronic books. $2 local $3 554714
690 $a 0786
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, San Francisco. $b Pharmaceutical Sciences and Pharmacogenomics. $3 1184261
773 0 $t Dissertation Abstracts International $g 79-01B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10288062 $z click for full text (PQDT)