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Burn-Induced Muscle Wasting : = Chan...

ProQuest Information and Learning Co.

Burn-Induced Muscle Wasting : = Changes in Muscle Progenitor Cells.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Burn-Induced Muscle Wasting :/
Reminder of title:	Changes in Muscle Progenitor Cells.
Author:	Yousuf, Yusef Abdi Hashi.
Description:	1 online resource (138 pages)
Notes:	Source: Masters Abstracts International, Volume: 57-05.
Contained By:	Masters Abstracts International57-05(E).
Subject:	Biology. -
Online resource:	click for full text (PQDT)
ISBN:	9780355812886

Burn-Induced Muscle Wasting : = Changes in Muscle Progenitor Cells.
Yousuf, Yusef Abdi Hashi.

Burn-Induced Muscle Wasting :Changes in Muscle Progenitor Cells. - 1 online resource (138 pages)

Source: Masters Abstracts International, Volume: 57-05.

Thesis (M.Sc.)--University of Toronto (Canada), 2018.

Includes bibliographical references

Severe burn results in a prolonged hypermetabolic response that leads to significant muscle wasting. This rapid loss in muscle mass occurs due to increased protein degradation and alterations in protein synthesis. The objective of our study was to examine the mechanisms of burn-induced muscle wasting. Using a mouse full-thickness scald burn model we show that muscle wasting after burn injury is associated with increased inflammation and a significant reduction in muscle progenitors. A reduction in this inflammatory cascade and a restoration of muscle progenitors leads to recovery of muscle size. We next examined whether we could attenuate burn-induced muscle wasting pharmacologically. Metformin treatment attenuated muscle wasting in part due to increasing the number of muscle progenitors and increasing their proliferation. Metformin treatment also reduced fat infiltration, a significant source of muscle damage after burn injury. Treating severe burn injury with metformin may mitigate muscle wasting in addition to managing hyperglycemia.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355812886Subjects--Topical Terms:

599573
Biology.
Index Terms--Genre/Form:

554714
Electronic books.

Burn-Induced Muscle Wasting : = Changes in Muscle Progenitor Cells.
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100 1 $a Yousuf, Yusef Abdi Hashi. $3 1193308
245 1 0 $a Burn-Induced Muscle Wasting : $b Changes in Muscle Progenitor Cells.
264 0 $c 2018
300 $a 1 online resource (138 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Masters Abstracts International, Volume: 57-05.
500 $a Adviser: Marc G. Jeschke.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2018.
504 $a Includes bibliographical references
520 $a Severe burn results in a prolonged hypermetabolic response that leads to significant muscle wasting. This rapid loss in muscle mass occurs due to increased protein degradation and alterations in protein synthesis. The objective of our study was to examine the mechanisms of burn-induced muscle wasting. Using a mouse full-thickness scald burn model we show that muscle wasting after burn injury is associated with increased inflammation and a significant reduction in muscle progenitors. A reduction in this inflammatory cascade and a restoration of muscle progenitors leads to recovery of muscle size. We next examined whether we could attenuate burn-induced muscle wasting pharmacologically. Metformin treatment attenuated muscle wasting in part due to increasing the number of muscle progenitors and increasing their proliferation. Metformin treatment also reduced fat infiltration, a significant source of muscle damage after burn injury. Treating severe burn injury with metformin may mitigate muscle wasting in addition to managing hyperglycemia.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biology. $3 599573
650 4 $a Medicine. $3 644133
650 4 $a Molecular biology. $3 583443
655 7 $a Electronic books. $2 local $3 554714
690 $a 0306
690 $a 0564
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710 2 $a University of Toronto (Canada). $b Medical Science. $3 1181466
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