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Development of Amyloidosis Typing Me...

Yang, Han-Yin.

Development of Amyloidosis Typing Method and Data Acquisition Strategies Using Tandem Mass Spectrometry.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Development of Amyloidosis Typing Method and Data Acquisition Strategies Using Tandem Mass Spectrometry./
Author:	Yang, Han-Yin.
Description:	1 online resource (103 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B.
Contained By:	Dissertation Abstracts International79-09B(E).
Subject:	Bioinformatics. -
Online resource:	click for full text (PQDT)
ISBN:	9780355850710

Development of Amyloidosis Typing Method and Data Acquisition Strategies Using Tandem Mass Spectrometry.
Yang, Han-Yin.

Development of Amyloidosis Typing Method and Data Acquisition Strategies Using Tandem Mass Spectrometry. - 1 online resource (103 pages)

Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B.

Thesis (Ph.D.)--University of Washington, 2018.

Includes bibliographical references

A variety of mass spectrometry acquisition methods are designed to maximize multiplexing capacity, quantification accuracy, or detection sensitivity of peptide ions in complex biological matrices. Data-independent acquisition (DIA) is an emerging method that aims to quantify proteins with high accuracy embracing the proteome complexity. With DIA, a novel strategy was proposed to predict amyloidosis types with a majority vote rule. Informative amyloid peptides were selected to cast the vote for specific amyloidosis types based on intensity distributions in disease populations.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355850710Subjects--Topical Terms:

583857
Bioinformatics.
Index Terms--Genre/Form:

554714
Electronic books.

Development of Amyloidosis Typing Method and Data Acquisition Strategies Using Tandem Mass Spectrometry.
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035 $a (MiAaPQ)washington:18354
035 $a AAI10751023
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Yang, Han-Yin. $3 1193317
245 1 0 $a Development of Amyloidosis Typing Method and Data Acquisition Strategies Using Tandem Mass Spectrometry.
264 0 $c 2018
300 $a 1 online resource (103 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B.
500 $a Adviser: Michael J. MacCoss.
502 $a Thesis (Ph.D.)--University of Washington, 2018.
504 $a Includes bibliographical references
520 $a A variety of mass spectrometry acquisition methods are designed to maximize multiplexing capacity, quantification accuracy, or detection sensitivity of peptide ions in complex biological matrices. Data-independent acquisition (DIA) is an emerging method that aims to quantify proteins with high accuracy embracing the proteome complexity. With DIA, a novel strategy was proposed to predict amyloidosis types with a majority vote rule. Informative amyloid peptides were selected to cast the vote for specific amyloidosis types based on intensity distributions in disease populations.
520 $a In contrast to DIA, the goal of data dependent acquisition (DDA) is to maximize the multiplexing capacity of peptide identification. Although DDA is a powerful data collection strategy, the majority of peptide ions in a complex mixture remain unanalyzed by tandem mass spectrometry (MS/MS). In this thesis, a novel acquisition approach, data dependent acquisition plus (DDA+), is proposed to improve sampling coverage by combing the characteristics of existing DDA and DIA methods.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Bioinformatics. $3 583857
655 7 $a Electronic books. $2 local $3 554714
690 $a 0715
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Washington. $b Genome Sciences. $3 1190110
773 0 $t Dissertation Abstracts International $g 79-09B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751023 $z click for full text (PQDT)

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