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Applications of Synthetic Microchannel and Nanopore Systems.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Applications of Synthetic Microchannel and Nanopore Systems./
Author:	Hinkle, Thomas Preston.
Description:	1 online resource (154 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.
Contained By:	Dissertation Abstracts International79-04B(E).
Subject:	Biophysics. -
Online resource:	click for full text (PQDT)
ISBN:	9780355413847

Applications of Synthetic Microchannel and Nanopore Systems.
Hinkle, Thomas Preston.

Applications of Synthetic Microchannel and Nanopore Systems. - 1 online resource (154 pages)

Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.

Thesis (Ph.D.)--University of California, Irvine, 2017.

Includes bibliographical references

This thesis describes research conducted on the physics and applications of micro- and nanoscale ion-conducting channels. Making use of the nanoscale physics that takes place in the vicinity of charged surfaces, there is the possibility that nanopores, holes on the order of 1 nm in size, could be used to make complex integrated ionic circuits. For inspiration on what such circuits could achieve we only need to look to biology systems, immensely complex machines that at their most basic level require precise control of ions and intercellular electric potentials to function. In order to contribute to the ever expanding field of nanopore research, we engineered novel hybrid insulator-conductor nanopores that behave analagously to ionic diodes, which allow passage of current flow in one direction but severely limit the current in the opposite direction. The experiments revealed that surface polarization of the conducting material can induce the formation of an electrical double layer in the same way static surface charges can. Furthermore, we showed that the hybrid device behaved similar to an ionic diode, and could see potential use as a standard rectifying element in ionic circuits.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355413847Subjects--Topical Terms:

581576
Biophysics.
Index Terms--Genre/Form:

554714
Electronic books.

Applications of Synthetic Microchannel and Nanopore Systems.
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245 1 0 $a Applications of Synthetic Microchannel and Nanopore Systems.
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300 $a 1 online resource (154 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.
500 $a Adviser: Zuzanna S. Siwy.
502 $a Thesis (Ph.D.)--University of California, Irvine, 2017.
504 $a Includes bibliographical references
520 $a This thesis describes research conducted on the physics and applications of micro- and nanoscale ion-conducting channels. Making use of the nanoscale physics that takes place in the vicinity of charged surfaces, there is the possibility that nanopores, holes on the order of 1 nm in size, could be used to make complex integrated ionic circuits. For inspiration on what such circuits could achieve we only need to look to biology systems, immensely complex machines that at their most basic level require precise control of ions and intercellular electric potentials to function. In order to contribute to the ever expanding field of nanopore research, we engineered novel hybrid insulator-conductor nanopores that behave analagously to ionic diodes, which allow passage of current flow in one direction but severely limit the current in the opposite direction. The experiments revealed that surface polarization of the conducting material can induce the formation of an electrical double layer in the same way static surface charges can. Furthermore, we showed that the hybrid device behaved similar to an ionic diode, and could see potential use as a standard rectifying element in ionic circuits.
520 $a Another application based on ion conducting channels is resistive pulse sensing, a single particle detection and characterization method. We present three main experiments that expand the capacity of resistive pulse sensing for particle characterization. First, we demonstrate how resistive pulse sensing in pores with longitudinal irregularities can be used to measure the lengths of individual nanoparticles. Then, we describe an entirely new hybrid approach to resistive pulse sensing, whereby the electrical measurements are combined with simultaneous optical imaging. The hybrid method allows for validation of the resistive pulse signals and will greatly contribute to their interpretability. We present experiments that explore some of the possibilities of the hybrid method. Then, building off the hybrid method we present experiments performed to measure single particle deformability with resistive pulse sensing. Using a novel microfluidic channel design, we were able to reproducibily induce bidirectional deformation of cells. We describe how these deformations could be detected with the resistive pulse signal alone, paving the way for resistive pulse sensing based cell deformability cytometers.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biophysics. $3 581576
650 4 $a Nanoscience. $3 632473
650 4 $a Nanotechnology. $3 557660
655 7 $a Electronic books. $2 local $3 554714
690 $a 0786
690 $a 0565
690 $a 0652
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of California, Irvine. $b Physics - Ph.D.. $3 1193413
773 0 $t Dissertation Abstracts International $g 79-04B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10634207 $z click for full text (PQDT)