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The Immune Impact of Common Sexually Transmitted Viruses and the Vaginal Microbiota : = Implications for HIV Susceptibility in African, Caribbean, and other Black Women from Toronto.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	The Immune Impact of Common Sexually Transmitted Viruses and the Vaginal Microbiota :/
其他題名:	Implications for HIV Susceptibility in African, Caribbean, and other Black Women from Toronto.
作者:	Shannon, Brett.
面頁冊數:	1 online resource (154 pages)
附註:	Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.
Contained By:	Dissertation Abstracts International79-12B(E).
標題:	Immunology. -
電子資源:	click for full text (PQDT)
ISBN:	9780438189201

The Immune Impact of Common Sexually Transmitted Viruses and the Vaginal Microbiota : = Implications for HIV Susceptibility in African, Caribbean, and other Black Women from Toronto.
Shannon, Brett.

The Immune Impact of Common Sexually Transmitted Viruses and the Vaginal Microbiota :Implications for HIV Susceptibility in African, Caribbean, and other Black Women from Toronto. - 1 online resource (154 pages)

Source: Dissertation Abstracts International, Volume: 79-12(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

Includes bibliographical references

Genital inflammation is a key determinant of human immunodeficiency virus (HIV) transmission and may increase the availability of HIV-susceptible target cells at sites of exposure. The African, Carribean, and other black (ACB) community is at increased risk of HIV acquisition in Toronto and several genital conditions that increase HIV risk are also more prevalent, including bacterial vaginosis, herpes simplex virus type-2 (HSV-2) and human papillomavirus (HPV) infection. Therefore, we assessed the impact of these three genital conditions on mucosal immune cells and cytokines in the female genital tract of ACB women. Endocervical cells and cervicovaginal secretions were collected by cytobrush and Instead Softcup, respectively. T cells and dendritic cells were assessed by flow cytometry, proinflammatory cytokines and chemokines by multiplex enzyme-linked immunosorbent assay (ELISA), and the microbiota by 16S ribosomal ribonucleic acid gene sequencing. HSV-2 infection was associated with elevated levels of endocervical HIV target cells (CCR5+ CD4 T cells), Lactobacillus -deficient microbiota was associated with elevated proinflammatory cytokines, prevalent HPV infection was associated with Lactobacillus -deficient microbiota, and HPV clearance was associated with higher numbers of Langerhans cells in the female genital tract. These results suggest multiple ways in which genital conditions are associated with factors that have been shown to influence HIV susceptibility and provides novel targets for future HIV prevention strategies.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780438189201Subjects--Topical Terms:

592892
Immunology.
Index Terms--Genre/Form:

554714
Electronic books.

The Immune Impact of Common Sexually Transmitted Viruses and the Vaginal Microbiota : = Implications for HIV Susceptibility in African, Caribbean, and other Black Women from Toronto.
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520 $a Genital inflammation is a key determinant of human immunodeficiency virus (HIV) transmission and may increase the availability of HIV-susceptible target cells at sites of exposure. The African, Carribean, and other black (ACB) community is at increased risk of HIV acquisition in Toronto and several genital conditions that increase HIV risk are also more prevalent, including bacterial vaginosis, herpes simplex virus type-2 (HSV-2) and human papillomavirus (HPV) infection. Therefore, we assessed the impact of these three genital conditions on mucosal immune cells and cytokines in the female genital tract of ACB women. Endocervical cells and cervicovaginal secretions were collected by cytobrush and Instead Softcup, respectively. T cells and dendritic cells were assessed by flow cytometry, proinflammatory cytokines and chemokines by multiplex enzyme-linked immunosorbent assay (ELISA), and the microbiota by 16S ribosomal ribonucleic acid gene sequencing. HSV-2 infection was associated with elevated levels of endocervical HIV target cells (CCR5+ CD4 T cells), Lactobacillus -deficient microbiota was associated with elevated proinflammatory cytokines, prevalent HPV infection was associated with Lactobacillus -deficient microbiota, and HPV clearance was associated with higher numbers of Langerhans cells in the female genital tract. These results suggest multiple ways in which genital conditions are associated with factors that have been shown to influence HIV susceptibility and provides novel targets for future HIV prevention strategies.
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