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Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults./
Author:	Yeung, Lok-Kin.
Description:	1 online resource (190 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.
Contained By:	Dissertation Abstracts International79-04B(E).
Subject:	Cognitive psychology. -
Online resource:	click for full text (PQDT)
ISBN:	9780355531121

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.
Yeung, Lok-Kin.

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults. - 1 online resource (190 pages)

Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2017.

Includes bibliographical references

Alzheimer's disease pathology first appears in the medial temporal lobe (MTL): in particular, in the anterolateral region of the entorhinal cortex (alERC). However, the scientific community has only recently begun to appreciate the importance of the subdivision of the human entorhinal cortex, and as such, our understanding of the alERC's cognitive roles and how it fits into models of MTL function remains limited. In this dissertation, I describe a series of studies inspired by findings from the animal literature, which shed light on the cognitive functions supported by the alERC. Using structural volumetry, I quantified the volumes of the alERC and other MTL regions in a group of ostensibly healthy older adults with varying degrees of cognitive decline. I compared participants' structural differences to their performance on behavioral tasks that we hypothesized represented cognitive functions supported by the alERC. Specifically, I investigated how alERC structural differences were related to performance on the Montreal Cognitive Assessment (MoCA), a standard neuropsychological assessment used in the diagnosis of AD (Chapter 2), as well as eyetracking-based behavioral tasks assessing intra-item configural processing (Chapter 3) and object-in-place memory (Chapter 4), cognitive functions which the rodent literature suggest are supported by the alERC. I found that participants who scored below the MoCA threshold score (indicating possible AD) had smaller alERC volumes (Chapter 2), demonstrating that alERC volume is related to cognitive decline. Further, intra-item configural processing -- regardless of an object's novelty -- was strongly predicted by alERC volume, but not by the volume of any other MTL subregion (Chapter 3). Finally, alERC (and parahippocampal cortex) volume was also related to object-in-place memory for items in everyday scenes, but no such relationship was found for object-trace memory (Chapter 4). Together, these studies suggest that the alERC may support aspects of the spatial processing of objects, advancing our understanding of the cognitive correlates of the alERC. More pragmatically, the alERC-specific tasks I developed may prove useful in early screening for AD and evaluating its progression.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355531121Subjects--Topical Terms:

556029
Cognitive psychology.
Index Terms--Genre/Form:

554714
Electronic books.

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.
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