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Role of Genes in the Jak-Stat Pathwa...

Lo, Amanda Susana.

Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster./
作者:	Lo, Amanda Susana.
面頁冊數:	1 online resource (56 pages)
附註:	Source: Masters Abstracts International, Volume: 56-06.
Contained By:	Masters Abstracts International56-06(E).
標題:	Biology. -
電子資源:	click for full text (PQDT)
ISBN:	9780355135572

Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster.
Lo, Amanda Susana.

Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster. - 1 online resource (56 pages)

Source: Masters Abstracts International, Volume: 56-06.

Thesis (M.S.)--University of Maryland, Baltimore County, 2017.

Includes bibliographical references

For many organisms, the immune system tends to deteriorate with age, leading to higher susceptibility to foreign pathogens. While several biological pathways are associated with immunity, the components of the Janus-kinase-Signal Transducers and Activators of Transcription (JAK-STAT) pathway on immunity at different age groups is unclear. This study explored the knock down effects of the Drosophila JAK-STAT pathway components and a candidate gene, robo3, in blood cells. Assessments of immune function were conducted through bacterial clearance assays and phagocytosis assay at one-week and five-weeks of age. This study suggests that some JAK-STAT pathway components important in other cell types seem to have less of a role in blood cells and immunity.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355135572Subjects--Topical Terms:

599573
Biology.
Index Terms--Genre/Form:

554714
Electronic books.

Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster.
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245 1 0 $a Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster.
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500 $a Source: Masters Abstracts International, Volume: 56-06.
500 $a Advisers: Jeff Leips; Michelle Starz-Gaiano.
502 $a Thesis (M.S.)--University of Maryland, Baltimore County, 2017.
504 $a Includes bibliographical references
520 $a For many organisms, the immune system tends to deteriorate with age, leading to higher susceptibility to foreign pathogens. While several biological pathways are associated with immunity, the components of the Janus-kinase-Signal Transducers and Activators of Transcription (JAK-STAT) pathway on immunity at different age groups is unclear. This study explored the knock down effects of the Drosophila JAK-STAT pathway components and a candidate gene, robo3, in blood cells. Assessments of immune function were conducted through bacterial clearance assays and phagocytosis assay at one-week and five-weeks of age. This study suggests that some JAK-STAT pathway components important in other cell types seem to have less of a role in blood cells and immunity.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biology. $3 599573
650 4 $a Immunology. $3 592892
655 7 $a Electronic books. $2 local $3 554714
690 $a 0306
690 $a 0982
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Maryland, Baltimore County. $b Biological Sciences. $3 1195269
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